Entrez gene ID | | 3638 |
Official gene symbol | | INSIG1 |
Full name | | insulin induced gene 1 |
Aliases | | ,CL-6,CL6,MGC1405, |
Gene summary | | Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q36 |
Gene position | | 155089486 - 155101945 Map Viewer |
Gene orientation | | plus |
Gene size | | 12460 bp |
Gene sequence |
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OMIM ID | | 602055 |
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