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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ITGAM (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3684
Official gene symbolITGAM
Full nameintegrin, alpha M (complement component 3 receptor 3 subunit)
Aliases,CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6,
Gene summaryThis gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p11.2
Gene position31271288 - 31344213  Map Viewer
Gene orientationplus
Gene size72926 bp
Gene sequence
OMIM ID120980