Entrez gene ID | | 374 |
Official gene symbol | | AREG |
Full name | | amphiregulin |
Aliases | | ,AR,AREGB,CRDGF,MGC13647,SDGF, |
Gene summary | | The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4q13-q21 |
Gene position | | 75310853 - 75320726 Map Viewer |
Gene orientation | | plus |
Gene size | | 9874 bp |
Gene sequence |
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OMIM ID | | 104640 |
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