Entrez gene ID | | 3827 |
Official gene symbol | | KNG1 |
Full name | | kininogen 1 |
Aliases | | ,BDK,KNG, |
Gene summary | | This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene. |
Location | | Chromosome: 3 Locus: 3q27 |
Gene position | | 186435098 - 186462199 Map Viewer |
Gene orientation | | plus |
Gene size | | 27102 bp |
Gene sequence |
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OMIM ID | | 612358 |
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