Entrez gene ID | | 397 |
Official gene symbol | | ARHGDIB |
Full name | | Rho GDP dissociation inhibitor (GDI) beta |
Aliases | | ,D4,GDIA2,GDID4,LYGDI,Ly-GDI,RAP1GN1,RhoGDI2, |
Gene summary | | Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM] |
Location | | Chromosome: 12 Locus: 12p12.3 |
Gene position | | 15114562 - 15094950 Map Viewer |
Gene orientation | | minus |
Gene size | | 19613 bp |
Gene sequence |
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OMIM ID | | 602843 |
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