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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LIMS1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3987
Official gene symbolLIMS1
Full nameLIM and senescent cell antigen-like domains 1
Aliases,PINCH,PINCH1,
Gene summaryThe protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q12.3
Gene position109150857 - 109303702  Map Viewer
Gene orientationplus
Gene size152846 bp
Gene sequence
OMIM ID602567