Entrez gene ID | | 4009 |
Official gene symbol | | LMX1A |
Full name | | LIM homeobox transcription factor 1, alpha |
Aliases | | ,LMX1,LMX1.1,MGC87616, |
Gene summary | | Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]).[supplied by OMIM] |
Location | | Chromosome: 1 Locus: 1q22-q23 |
Gene position | | 165325952 - 165171104 Map Viewer |
Gene orientation | | minus |
Gene size | | 154849 bp |
Gene sequence |
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OMIM ID | | 600298 |
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