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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LOXL2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4017
Official gene symbolLOXL2
Full namelysyl oxidase-like 2
Aliases,LOR2,WS9-14,
Gene summaryThis gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq]
LocationChromosome: 8   Locus: 8p21.3-p21.2
Gene position23261722 - 23154410  Map Viewer
Gene orientationminus
Gene size107313 bp
Gene sequence
OMIM ID606663