Entrez gene ID | | 4049 |
Official gene symbol | | LTA |
Full name | | lymphotoxin alpha (TNF superfamily, member 1) |
Aliases | | ,LT,TNFB,TNFSF1, |
Gene summary | | The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis. |
Location | | Chromosome: 6 Locus: 6p21.3 |
Gene position | | 31539876 - 31542098 Map Viewer |
Gene orientation | | plus |
Gene size | | 2223 bp |
Gene sequence |
| |
OMIM ID | | 153440 |
|