Entrez gene ID | | 405 |
Official gene symbol | | ARNT |
Full name | | aryl hydrocarbon receptor nuclear translocator |
Aliases | | ,HIF-1beta,HIF1B,HIF1BETA,TANGO,bHLHe2, |
Gene summary | | The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q21 |
Gene position | | 150849186 - 150782186 Map Viewer |
Gene orientation | | minus |
Gene size | | 67001 bp |
Gene sequence |
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OMIM ID | | 126110 |
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