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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LTB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4050 Official gene symbol LTB Full name lymphotoxin beta (TNF superfamily, member 3) Aliases ,TNFC,TNFSF3,p33, Gene summary Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 31550202 - 31548335  Map Viewer Gene orientation minus Gene size 1868 bp Gene sequence >LTB:complement(3057951..3059818):Length=1868 CAGTCTCAATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTT CCCTCCTGCTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTA TCACTGTCCTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTGAGTGGCT GCAACAGGCCCTGGTGGAGAGTTGTATCTTGCGGATGCTTGGCTCCCTCTGGTTGTGCCT GTGGTCTTTTGCCCCCTCTGGCTCAGCTGGCTCGGCTGTCCCTGGTGGGGATGTCTTGTC TCTTTGCTGACTCTCTTTCCATGTTCCTGTGATGTTGTGCTTGTGTCCCGACATAAGCCC CTTGTGTCTCCTCTCCTCTTCCCGAGGTACATCTGTTTCTCCGCCCAAGTACCTATGCCT TGCTTGTTCTCCCTTCTAAGGAGGTGTGTGTTGGGGATGGTGCTGGTAGGAGAAACCCCA GGCCTGCAGCTTGGGTCCACTTTCAGAGGGGTAGGGGTGACATGAGCTGAATCTGAACTC TGGGCACTGTGACCCCACCCAACCAGGTAACGGAGACGGCCGACCCCGGGGCACAGGCCC AGCAAGGACTGGGTAAGAGCAGACTGTCTCTCCTTCCCCGCTTCAGACCCTCAGGGGCTC CCAGCTCCCTGCTGCGTCCCCAGATACCTCTTCCTCTAGGAATCCAGGCTCCCCATCCCT GCGCCCTGTTCTCTCAAGGGTAGCCTGCATGGGTGGCTGCCCTGCCCCCAATCGTGGACT CTTTGCCCCTTCCAGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAAACAGATCTCAGCC CCGGGCTCCCAGCTGCCCACCTCATAGGTAAGGACCTCCAAGACCTGAATAAGAGTGTAA ATAATCCGAAGGTTCCAGTTCTGCTCGCCCAGAGTCCTTCGGCTCCATGATTCCAGTGCT CGGTTTCCCACCCGCTTCACGACCTTTTGTCGCTCGTGCCCACTCTTACGCTCGTCCCCG CAGTGTAGTTTCTTCTTCCCTCCGGTGCAAGCAAAAGCCGGCCTGGAGGTCCCCACTACA GCGTTCTGCACCCCACATCCGTGTTCCCTCGGCCCCCAACTCGCACTCATCCCAGAAACA GCACCATCCCTCCTCCCCCGGCCCGGCTCGGCTCCCGCAGGGGCTAAAAGCCGCCACTTC CCCAGAAGTCCCAAGCCTTTAGGATCGCATTCCCAAGAGCGCGTCGGCCCGTGTCTCCGC AGGCGCTCCGCTGAAGGGGCAGGGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCT GACGAGCGGGACGCAGTTCTCGGACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTA TTACCTCTACTGTCTCGTCGGCTACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCA GGGCCGCTCGGTCACGCTGCGCAGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGG CACTCCCGAGCTGCTGCTCGAGGGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAG GAGACAAGGGTACGGGCCTCTCTGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCT CCGGAGGGGCGAGAGGGTGTACGTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAG AGGGAAGACCTTCTTTGGGGCCGTGATGGTGGGGTGAGGGAATATGAGTGCGTGGTGCGA GTGCGTGAATATTGGGGGCCCGGACGCCCAGGACCCCATGGCAGTGGGAAAAATGTAGGA GACTGTTTGGAAATTGATTTTGAACCTGATGAAAATAAAGAATGGAAAGCTTCAGTGCTG CCGATAAA OMIM ID 600978