Entrez gene ID | | 407975 |
Official gene symbol | | MIR17HG |
Full name | | MIR17 host gene (non-protein coding) |
Aliases | | ,C13orf25,FLJ14178,MGC126270,MIHG1,MIRH1,MIRHG1,NCRNA00048,miR-17-92, |
Gene summary | | MicroRNAs (miRNAs) are small regulatory RNAs that control gene expression by binding to complementary sites within target mRNAs and mediating their degradation or translational repression. MIR17HG is the host gene for the MIR17-92 cluster, which is also called ONCOMIR1, and encodes a polycistronic primary transcript that yields at least 6 mature miRNAs: MIR17 (MIM 609416), MIR18 (MIR18A; MIM 609417), MIR19A (MIR19A1; MIM 609418), MIR19B (MIR19B1; MIM 609419), MIR20 (MIR20A; MIM 609420), and MIR92 (MIR92A1; MIM 609422). MIR17-92 functions in cell survival, proliferation, differentiation, and angiogenesis and is the primary target of genomic amplification of chromosome 13q31 that occurs in several lymphomas and solid tumors (summary by Olive et al., 2009 [PubMed 20008935]).[supplied by OMIM] |
Location | | Chromosome: 13 Locus: 13q31.3 |
Gene position | | 92000074 - 92006829 Map Viewer |
Gene orientation | | plus |
Gene size | | 6756 bp |
Gene sequence |
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OMIM ID | | 609415 |
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