Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ARRB1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID408
Official gene symbolARRB1
Full namearrestin, beta 1
Aliases,ARB1,ARR1,
Gene summary Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q13
Gene position75062873 - 74976482  Map Viewer
Gene orientationminus
Gene size86392 bp
Gene sequence
OMIM ID107940