Entrez gene ID | | 408 |
Official gene symbol | | ARRB1 |
Full name | | arrestin, beta 1 |
Aliases | | ,ARB1,ARR1, |
Gene summary | | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q13 |
Gene position | | 75062873 - 74976482 Map Viewer |
Gene orientation | | minus |
Gene size | | 86392 bp |
Gene sequence |
| |
OMIM ID | | 107940 |
|