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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MATK (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4145
Official gene symbolMATK
Full namemegakaryocyte-associated tyrosine kinase
Aliases,CHK,CTK,DKFZp434N1212,HHYLTK,HYL,HYLTK,Lsk,MGC1708,MGC2101,
Gene summaryThe protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13.3
Gene position3801810 - 3777967  Map Viewer
Gene orientationminus
Gene size23844 bp
Gene sequence
OMIM ID600038