Entrez gene ID | | 4215 |
Official gene symbol | | MAP3K3 |
Full name | | mitogen-activated protein kinase kinase kinase 3 |
Aliases | | ,MAPKKK3,MEKK3, |
Gene summary | | This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q23.3 |
Gene position | | 61699801 - 61773670 Map Viewer |
Gene orientation | | plus |
Gene size | | 73870 bp |
Gene sequence |
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OMIM ID | | 602539 |
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