Entrez gene ID | | 4218 |
Official gene symbol | | RAB8A |
Full name | | RAB8A, member RAS oncogene family |
Aliases | | ,MEL,RAB8, |
Gene summary | | The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19p13.1 |
Gene position | | 16222490 - 16244445 Map Viewer |
Gene orientation | | plus |
Gene size | | 21956 bp |
Gene sequence |
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OMIM ID | | 165040 |
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