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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RAB8A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4218
Official gene symbolRAB8A
Full nameRAB8A, member RAS oncogene family
Aliases,MEL,RAB8,
Gene summaryThe protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13.1
Gene position16222490 - 16244445  Map Viewer
Gene orientationplus
Gene size21956 bp
Gene sequence
OMIM ID165040