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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MGST1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4257
Official gene symbolMGST1
Full namemicrosomal glutathione S-transferase 1
Aliases,GST12,MGC14525,MGST,MGST-I,
Gene summaryThe MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform. [provided by RefSeq]
LocationChromosome: 12   Locus: 12p12.3-p12.1
Gene position16500076 - 16517344  Map Viewer
Gene orientationplus
Gene size17269 bp
Gene sequence
OMIM ID138330