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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ACHE (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 43 Official gene symbol ACHE Full name acetylcholinesterase (Yt blood group) Aliases ,ARACHE,N-ACHE,YT, Gene summary Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq] Location Chromosome: 7   Locus: 7q22 Gene position 100493541 - 100487615  Map Viewer Gene orientation minus Gene size 5927 bp Gene sequence >ACHE:complement(38520458..38526384):Length=5927 GGGGTGTGTGCGGGGGGCCGGAGGCGGCGGCTGTCAGAGTCGGCTCAGCCTGCGCCGGGG AACATCGGCCGCCTCCAGCTCCCGGCGCGGCCCGGCCCGGCCCGGCTCGGCCGCCTCAGG TGAGTCTCCCTCCCCGCCCGGGACTCTCCTTAAGGCCCGGGTCCGGGGCACCGTGCGCTC CCCGAGGGGTCCAGGCCCCCCTAACGGGACGGCTCCCGCTTCCCCGGGCCTGCCCCGCGC CGCCCTCCGCTGCCCCGCACTCGTCCGGAACTCTTCCCCGGCCGCCTCACACTCACCGAC GCCCACGCAGGAGCCCGAGCCCGCGGGAACGGCCGCCGCCTCTGCGCTCCGATTCCCGCG GGGACCCCCGAGCACCCCTTCCCCGATCGCTCCCTAGTCCGGGGCCACTGGAAGACACCC CCTAATTGGGGCGGTACCCGAGCTGCGCAGGTTCCCGGCGCCGGGCTGGGCACCCCCATC CCCAGGGCCACAAGCCAGCGCCCCTGCGCAGCGCCCCGCAGAGGCCCCCTCCGAGGCCCA GGACGCCCCCTCCCGCGGAGACTCCATCTCTATTTTTTGGGAAGGGGAGGCTCGGCGGAA GCCCCGAGTTATAATTAGCGCCACTCGGGTTTCCTAGTTAATCTCCAGCAGCACCACCAC CCCCCGCTCAGGGCGGCGGGGGCTGGGCTAGGAGTGACCGGCGGGAGAGGGGGGAGTTCC CACCCGGGGAATTTTGATCCTTTGGCTGGAGATGCCGGAACCGTAGCAGCTGCTGCCCCC AAAATAGCGCCCCCGCCCCTGCAGCCGGGGATCTCCGGAGTCCCGGGAACGCAGGCGTCC CGGCTCGCCCTTCAGGCGGCTCTGCAAGGCCCTCGAGCCCCCAGGCCCCCTCCCCAAGTT CCCGGCTCCTGGCTCGGGGCGGGGAGCGCCGACCTTTTCTCGGTCTCTACTGCCCTCCGC CGGCGGCGGCGTGCACGGCAGCTTCAGACGGATGGGGGGCTCTCGAGTCCTGGGGGACGC GGGCTGGCGAGCCTGTTTGCTGGGGCTGGGCTGGGAGCGTGCGCAGCTGATGGGAACCCG CGGGCATCAGCGCTCGGTGCCAGACATTGGATGAGAAGGGGCAGGGTTGGGTGGGGAGTG GACTAGGCAGGATTTGGGGGACCCCGGGACCTGAGGCTTCCACACCCTGAATGCCCAGCC CACCGCCCCCCAGGGCCCCGGGTCTGGCCGACCCAGGAGAGCGGGGCTGCGCTTCAGGCC GCCGCAAGCTCCCCCAGCGGCGCTGCCCGTCCGTGAGGCCGCGCCCTGTCGGGTGGCCTG TTCGTGGACTGAGGCTTCTGGTGCCCTCACTGCACGAGCTGGGCCCGGCCCAGTTCCGGG AAGAGGTGAGGGCAGTGGACCCCTGCGGAGCAGAGAGGGTGCTCCTCTCTGTTCCCTGCA TTTGTCTGGATATGGGTGTCTGCCTGATCTCTTTCCCCTCCTGCCCGCTGGCCTGTGTCC TTGTCTCTGCCTGTCTCCTTCCCTCCCTCCCTCTCTCCCCTCATCTTTGCCAACCTGCCC CACCTCCTCTGCAGCTGAGCGATAACCCTTGGGCCGACAGTGCCCTAATCTCCTCCCTCC TGGCTTCTCGACCGACCCTTCACCCTTTCCCTTTCTTTCTCCCAGCAGACGCCGCCTGCC CTGCAGCCATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCC TTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAG AGCTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGG GCCCTGTCTCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCT TTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGA GTGTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGA ACCCCAACCGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCC GGCCTACATCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGG CCTCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGG TGTCCATGAACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGG CCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACG TGGCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCG CCTCGGTGGGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGC TGCAGAGCGGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCA GGGCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACA CAGAGCTGGTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGC ACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACT TCCTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTAA CTAGTGGCTAGCTGGCGTGAAGCTGGCTCCTCTGGGTCCCAACGGTCCCTCCCCTCCCTG CAGGGACCCAGGCATGAGGGCTTCTCCAGGCCCATTCCCAGAAGTCCCAGAAGTCCTCCC TGAGGGCTCAGATCCCAGGGTGGTCAGCAGGGCAGACAGGAAAGCCACCATGGGTCTATT TTCTCTTTCTCTGCATCCCTCCCCTGATCTCGTCCTCTCTCTGTCCATGGTTCCGGGTCT GTAACTGTTCATCTCTCTGGCTCTTTGTCTGTCCATCTGTTTCTGTCTACTTGTCTGTCT GTGCCTGTCGCTCCATCCCACCCCCCTCTCCCTCACCCCCAGGTGCTGGTGGGTGTGGTG AAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGACAACGAG TCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAGGTAAGT GACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAGGACCCG GCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGCCCCGTG GCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTCTTTGAA CACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTACGAGATC GAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAGAAAATC TTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGTCAGCAGTGCAG AGGGAGAGAAGGCTGGGGAGGACAGGAGTCGGGGGCGGGAGGACACACAAAGGCAGACAC ACGGAGACAGAAAGGACGGGTGGGACAGGGGCAGGATAGAACAGCCAGAGAGGGATATGC TCACAAAGTAGATAAAAGGGGAGAGAAAAAGAAAGGAGACAGAGAAGGCAGAGGGGGTCT TGCAGAGACAGAGGCAAAGGAAAGTGAGGAGGAGACGAGGTAGACATGGAGGGGGCGGGG CACAGTGGCTCACCCCTGTAATTCCAGCCCTTTGGGAGGCCAAGGTGGGAGGATCCCCTG AGGCCAGGAGTTTGAGACCAGACTGGACAACATAACAAGACCCCGACTCTTAAAAAGAAA AAAAATACAAAACTTAGCCAGGCACGGTGGCTCGTGCCTCTAGTCCCAGCTACTTGGGAA GGTGAGGCAGGAGGATTGCTTGAGCCTGGGAGGTTGAGGCTGCAGTGAGCTATGATGGCA CCACTGCACTCCAGCCTGAGTGGCCCTATCTCTGGAAAAAAAAAAAAAAAAAAAAAAGGG AGACCAAGACAAAGGAGTTGGAGCTGGATTAAGTCAAACCAGTGATGATTCACTAGCAGT GACACATTCTCTCACACACACACCAGTTTACCTGGATCGAGAAGAGGACAATGAAATCTA GCATTGGATGGGTGTTGTTAAAAAATGTGATGTTTGTAGACATAGGACCCGTCCTGGTTA TTTAGGAAAGTCTCAAGACATCCTAGCCATTTTTTTAGTGAGAGAAACAAAGATGGAACA GAAAAGCTGAGGGAAACGGAAGGAGACGGAGCGCTTGAGGAAGGGAAGACCCCAATGACC GCGCACATTGGAGAAAGTGGTGGGAGGGAGGGGACGGGTTCTCTGGGGCTCTCCGCTGAG CTGAAGAGTCCGGGATCCCGTGGAGTTGGGGGCCACCTCCTCCCACTGCCCGTCTGGACT GAGCCTTCCCTTCCTTCCGCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAAT GGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGTCTGGACCTGCGGCCGCTGGAGG TGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGC TCAGCGCCACCGGTATGCAGGGGCCAGCGGGCAGCGGCTGGGAGGAGGGGAGTGGGAGCC CGCCAGGTGTAACCCCTCTCTTCTCCCCCTAGCCTCGGAGGCTCCCAGCACCTGCCCAGG CTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTGCCCCTCCTCCTCCTCCA CCAGCTTCTCCTCCTCTTCCTCTCCCACCTCCGGCGGCTGTGAACACGGCCTCTTCCCCT ACGGCCACAGGGGCCCCTCCTCTAATGAGTGGTCGGACCGTGGGGAAGGGCCCCACTCAG GGATCTCAGACCTAGTGCTCCCTTCCTCCTCAAACCGAGAGACTCACACTGGACAGGGCA GGAGGAGGGGGCCGTGCCTCCCACCCTTCTCAGGGACCCCCACGCCTTTGTTGTTTGAAT GGAAATGGAAAAGCCAGTATTCTTTTATAAAATTATCTTTTGGAACCTGAGCCTGACATT GGGGGGAAGTGGGAGGCCCCGGACGGGGTAGCACCCCCCATTGGGGCTATAACGGTCAAC CATTTCTGTCTCTTCTTTTTCCCCCAACCTCCCCCTCCTGTCCCCTCTGTTCCCGTCTTC CGGTCATTCTTTTCTCCTCCTCTCTCCTTCCTGCTGTCCTTCTCCGGCCCCGCCTCTGCC CTCATCCTCCCTCTCGTCTTTCGCACATTCTCCTGATCCTCTTGCCACCGTCCCACGTGG TCGCCTGCATTTCTCCGTGCGTCCTCCCTGCACTCATACCCCCCCTTCAACCCGCCCAAA TGTCCGATCCCCGACCTTCCTCGTGCCGTCCTCCCCTCCCGCCTCGCTGGGCGCCCTGGC CGCAGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTC CTACATGGTGCACTGGAAGAACCAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGA CCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCCCCTAGCTGTATATA CTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACC CCACCCCGACGTCCCCCGGGGCTCCCGGTCCTCTGCATGTCTCAGGCTGAGCTCCCTCCC CCGCGGTGCCTTCGCCCCTCTGGGCTGCCAATAAACTGTTACAGCCA OMIM ID 100740