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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MMP2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4313
Official gene symbolMMP2
Full namematrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Aliases,CLG4,CLG4A,MMP-II,MONA,TBE-1,
Gene summaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 16   Locus: 16q13-q21
Gene position55513081 - 55540586  Map Viewer
Gene orientationplus
Gene size27506 bp
Gene sequence
OMIM ID120360