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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ASL (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 435 Official gene symbol ASL Full name argininosuccinate lyase Aliases ,ASAL, Gene summary This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] Location Chromosome: 7   Locus: 7cen-q11.2 Gene position 65540776 - 65558330  Map Viewer Gene orientation plus Gene size 17555 bp Gene sequence >ASL:3573619..3591173:Length=17555 GACGCCATCCCGGCCAGAAAAGCCCTGGCCAGTGGCGGGCGCGACACTATCCGTGCGGCC AGGCGGAGGTGAGTGCGCGGCGGCCGGATGGGCGGGACGGGCGTGGAGGACGCCGAGCAC CGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAAGCGCAGTGCCCAG AACTCGGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCT TGTCTTCCAGACCCGGAGGACCGAAGCTTCCGGACGACGAGGAACCGCCCAACATGGCCT CGGAGGTGAGTGGGACCTCGGGGACTCCGGTCCTCCTAGCCTCCAAAGGAGAGAGTGGGG GCGCCAGACCTGCCTCGGGCCACCCTGCTGGGAATCGCCCTCCAGGAAGCAATTTTGAAA ATTACCTAGGAAGCCTGCACCCCCAGCCCTCCCGGGCGCATCATCTGGAGCCCAGCAGTC ACCTTTACCAGGACTCACCAGTATCCGCAGGCAGCCCTTGTGGCAAACCCACCAACCCAC ACTACTAGGGGTAGAGTGGCTCTGCCCTCACCTCACAGTGATGCCTGCCTGGCCAGGAAA AGTGGCTCCCAAGCCTTCAGCCTTCCAACTCTTCCTTCCTTCTTACCACGTGTCCTCCTG TCAGGTCCCACCCCACACCACATCCCTTCTCCTGCTAGAGCAATTGTCCCTGTTTATAGA ATAAAGCTCAGCCCCTAAGTGTTCTTGTCCTTGACTGTGGCATGTGGAAAGAGCCAGGAA AAAGGGGACGTCGCCTCGTGGCTCCAGCAACCCTGGTGCCTGGTCCCTTCCTGTCTCACT GGACCCTGCCTCTTAGGGTCAGTGGCTCCTGGCCTCTCCTCCTGACCACTGAGATGCTGG ATTCCCAGGCAGAGGTTTTCCTTCCTTGGGCCATAGTTGATTTATCTGGCAATGGGGGTA ATAATAGCTGTCGGCCTCACTCTGTAAGGCACTAGATTATGAGGCCATTGCTTTGGACCC TTCAGGTGAGAGGGGCTGTTCGCCTGATGCTTGATGAAGGGAACTCCGGGAAGCAGGAGG TCTGGGTTCCAGGCCCTTTTGGCCTTCATTAGCTAGCAATTCACTTCCTCTTTCTCAATG CCCTGCAAGCTCAGTGCCCTGCAAGCTTCTGGGTCATGGCAGGGGGGTAGGGCCTGGACT TTGGAGCCAAACAGACTTGGTTTCTGTACCAGTCACTTGAGCCCTTTAAACCTCTTTCCT CATTTGTGAAATAGGGGTAATATTGCCCACCTCATAAAAGGCCGTAATAACATATGTGAA ATCCCTAGCACAGGGCTGAGCAACAGTAGGTGCTCAATAAATGGTGGCTAACCACAACAA TACTGATATTTCTACTTTGGGAGGCCGAGGCGGGAGGACTGCTGAAGCCCAGGAATTCCA GACCAGCCAGGGCAATGTAATGAGACCCTGTCTCTACAAAAAGATTTTGAAAATTACCCA GGTGTGGTGGCGTACACCTGTAGTCTCACAGGAGGCGGAGGCATGAGGATTGCTTGAGCC CAGGAGTTTGAGACTGCAGTGAGCATGATCTCACCACTGCACTCCAGCCCAGGCAACAGA GTGAGATCCAGTTTCAAAAAAATAAAAATAAAAAAACCTGGCAGGCATGGTGGCTCACAC CTGTAATCCCAGCACTTTGGGAGGTCGAGGTGGGCAGATCACCTGAGGTCAGGAGTTTGA GACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATGCAAAAATTAGCTGGG TGTAGTGGTGGGTGCCTGTAGTCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATCGCTTG AACTCGGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCG ACAAAGCAAGACTCCACCTCAAAAAAAGAAAAAAAACCCACAAGTCCCAAAACCAAAACT GGTATTTCCCATGTACATTCGACCTTAACTGTTGCTCATTCAACCCAGCCCAACTCAGTG CCCCATCCCCTGGCCCTGAAGAGACCATTCTGGCCCAGATGTGTCCTGGCTTGGAGTAGC ACCTTCTGCTACCACACTAGGCCTCCACTCTCCTCAGTGCCCAAGGGGAGGCACCTCACT CTGATCTCCCTGTGGGGTCCTCTTATGCCTGCCAGTAAGGATAGGAGTTTGGTTCTAGAG CAGAGTGGTCTGGCTTCCAACAAGCCCAGTGTTCTAGGTGACCTCAGGTTGCCCCAGGCC TTCCTGTAGGTTGGCACTAATTGGTTTGGCTGCAGCTCCACTTATTAAGTAGTTATTTTT ATTACTAACAACCTAGGCAGGGTGGCCCAGGAGCCCGCTGGGGGAGGCGGTGCCAGGCTC CTGGCTGAGGGGCAGGCTGGCCCCAATTCTGACTGGCTGGCTCCAGTGATCAGGACCAGG GCCCCACGTGGTGCTTTGCTGGAGATCTAGGCTTGGTGGGGCAGCTGTGGGGTAAGGGGC AGGACCAGCTCAAAGATGGGGTGGGGGCGGAGGCTGCCTCTGCAGGGCAGAGTCCTTTGG CAGTCGGGACTGTTGGGCATAGAGGAGTCAGCTCACAGCTCAGGGCCAGAGCACTGGAGA GGTCTCTGGGGTGCATACAGGAACCAGGAGTGGAGCTGAAGCATGTCCTATCCCCTGCCA GCCCTCCCTTAGTAACAGCTGGCATTTCTCGAGTCCTTCCTGAGCACCAGGCACCGTGTT ATGTATGCAATTTGCAAATATTATCTGATTAAATGCTCACAATAAGGCTATCAGAGAGGT ACTATTATTATCCTTATCTTATTATTATTATTATTATTATTTTTAAGAAGGAGTCTTGCT CTGTCGCCCAAGCTGGAGTACAATGGCGCCATCTCTGCTCACCGCAACCTCTACCTCCAG GATTCAAGTGATTCTCCTGCTTCAGACTCCCAAGTGGCTGGGACTACAGCTTCCTGCCAC CGCGCCTGGCTAATGTTTATATTTTTAGTACAGATGAGGTTTCACCATGTTGGCCAGGCT GATCTCGAACTCCTGACCTCAAGCGATCCACCTGCCTGGGCCTCCCAACCCTGAGGGTTT TTGTTTTTGTTTTTGTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTG GCACGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAG CCTCCCAAGTAGCTGGGACTACAGGCGCCCAACACCCCCATGCCTGGCTAATTTTTTTGT GTGTGTTTTCAGTAGAGACGGAGTTTCACCATGTTAGCCAGGATGGTCTCCATCTCCTGA CCTCGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTAGGATTATAGGTGTGAGCCACCAC GCCCAGCCCCTGAGGTTTAATAATAGGTGCCAGGCCAGGTGGTTAATAGAAGTCTGGGGC ATTGTAGGGGGACAGAGGAGGATATATGTCCCCATTGGCCATTGTAGACTCCCTTCCACA AAAAGGACGTCAGTGAAGTGACATGCCCACCTCTACCCCACCCTCCTCCCAGTCCTGGGC ACTAGGGCTGCTCCCCAGGTGTTCTGTACCCCCTCCCCACTCTGTCCCATGCCCTGGCCT CTGCCCTCTTTCAAAACATAGATGTGGCTGGCGCCTAGGCTCATGCCTATAATCTCAGCA CTTTGGGAAGCTGAGGCTGGAGGACAGCTTGAGCCCAGGAATTCAAGACCAGCCTGGGCA ACATAGTGAGACCCTGTCTCTACCAATTATTTTATTTTATTTTATTTTGTTCATTTATTT ATTTATTTTGAGACAGAGTTTTGCTCTGTCACCTAGGCTGGAGTGCAGTGGCGTGATCTT GGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTAAGT AGCTGGAACTACAGGCGAGTGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGAC CAGGTTTCACCATGTTGACCAGGATGGTCTCTGTCTCCTGACCTCATGATCCACCCACCT TAGCCTTCCAAAATGCTGGGATTACAGGCATGAGCCACCACTCCCAGTCCTATAAAATTT TAAAAAAATGTCTGGGTGTGGTGGCGCATGCTTGTAGTCCCAACTATTGGGGAGGCTGAG GCAAGAGGATTGGTTGAGACCAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACCG CACTCCAACCTGGGTAACAAAGTGAGACCCTGTGTCTAAAAAAGAATTTAAAGGCCGGGT GTGGTGGCTCACACCCGTAATCCCAGGACTTTGGGAGGCCGAGGTGGGCAGATCACGAGG TCAGATTAAGACCATCCTGGCTAACAAGGTGAAACCACGTCTCTACTGAAAAAAAAAAAT ACAAAAAATTAGCCAGGCATGGTGGTGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGA GGCAGGAGAATGGCGTGAATCTGGGAGGTGGAGCTTGCAGTGAGCCAAGATCCTGCCACT GCACTCCAGCCTGGGTGACAAAGAGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAGA ATTAAAAAAGATTTTTTTAATGAACAAAACAGGCTCGGCACAGTGGCTCATGCCTGTAAT CCCAAGCACTTCGGGATGCCAAGGTCAGGGGATCACCTGAGATCAGGAGTTCGAGACCAG CCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAACTCAGCCAGGTGTGGT GGCACACGCCTGAAATTCCAGCTACTCGGGAGGCTGAGGCAGGAAAATTGGCTTGAAGCC GGGAGGTGGAGGTTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGA GTGAGACTCTATCTCAAAGAAAACGAACAAAACATAGATGCCTACATACCATTCCTCTGC CCTTGGCTCCTGGGGAGTAAGGGATCACCCAGTGACCTCCTAGAAGGCCAGTGACAATGG GGGGTGTCAGGGTGCTTTTCAGAGCCAAGGGAGTGGTAGGAATTGGGATCTTAGTCCAGC TCCAAGCTGTGAGGGAGAGAGTTGCAGGGCACTTAAGCTTGGTGGAGACCCTCAAGGCCT CTTTGCCTGTCCCTGCAGCAAAGGTTCTGGACACCAGAGCCAAGTCCAGAAGCCCTGGTG GAACAGGGGTGAAAAGCATAGGTTCTGACTTCAGACTGCTGGGCCGCAGCCCTGGCTATC CCACCCCAGGTGAGAGCAGGCTGCTCTGTGCCTCAGTTTCCCCATCTTCATAGTGGAATT GTATTGGTGCCTACCCAGAGGGTTGTGTCAACAATTAGGATGGCACCTAGCACCTTGGTC AGTGGTGGGAAAGGTTCCAGAAGTTCTGCTGTGGTCCCAGGGGTGTCTCAGGCCCTGCCA TCATCTCCTTGGAGGGGTGCCATGTGGTGGGAAAGAACCCCAACTTCAAGGCCACACACA GTGGCTCATGCCTGTAATCCTAGCACTTTCAGAGGCCAAGATGGGAGGATCACCTGAGGT CAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAATGATACAAA AATTAGCTGGGTGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGTCTGAGGCAGG AGAATCTCTTGAACCTGGGAGGCAGAGTTTGCAGTGAGCTGAGATGGCACCACTGTACTC CAGCCTGGCCGACAAAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAGAACCCAAACTTTT GGTGTTCAGCCATGTTCCCATGCTCACTCCCAGGGTGGTGACTCTGGGAAGGTCTCAGCC TCCTTGTCTGCCCAGTTAGAATGATCTGATGCCCCTGCTACCATCAGACTTGATAAGTTT CCCAAAGACTCTTTGCAAGAAGCACTGTTCTGGAGGGTGGAGGAGAGACTAATTGTTCTT GCTCTCCTGGCCAGAGTGGGAAGCTTTGGGGTGGCCGGTTTGTGGGTGCAGTGGACCCCA TCATGGAGAAGTTCAACGCGTCCATTGCCTACGACCGGCACCTTTGGGAGGTGGATGTTC AAGGCAGCAAAGCCTACAGCAGGGGCCTGGAGAAGGCAGGGCTCCTCACCAAGGCCGAGA TGGACCAGATACTCCATGGCCTAGACAAGGTACTTGCCGTGGCCCAAGCCCCACCCAAGG CCCCTTCCCTGTGGCCCCAGGCTCCCACCAAATCCCTGAGCAAACAGTGCAGTGTTGCCC ATCTGTGGTTTCACATTGAACTAATTATATACTCAAGTGCTGTTTAACTGTGTGCCTTGA TGACTGCCTCTCTCCATCCTTTAATGACCCCTGTGGCCCACATGGCTCATGGGTAAAGGT GTGCTGGGCCTGAGATGCCCCCTCCCAGGGTGCGCTTCCAGGACTCAGCTCCTGGGCAGG GACAGTCAGTCACCAGGGATAGGGTGGGACCAAGGCAGGGGCTCTCTTGGCTGCTGATGC CTGCTCACCTGACCCCGGCATTGCTGCTACCCACTACAGGTGGCTGAGGAGTGGGCCCAG GGCACCTTCAAACTGAACTCCAATGATGAGGACATCCACACAGCCAATGAGCGCCGCCTG AAGGTACGACCCCTGGAGCCCCACCGCTTTCCTTGCCTCCCCTCTCCACCTTGCCCAGGG CCACTTTGAGCATTAGCACCATTCTGTTTACTTCGCCATTGGCAGACAGCATGTGAGACC TCAGGACATGAGCCAGGCACCCTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCTGA GGTGGGAGGATTGCTTGAGACCAGGAGTTCGAGACCAGCCTGGGCAACATAATGAGGTCC CACAGCTACAAAAATTAAAAAAAGAAAAGAAAAAAAGAACAGGCCTCAGCAGAAATGGCG AGAGATTTGGGGAGGACCCGGAGCCCTGGGGTATGGAGGTAGGTTGGCAGGGCTGATGAG GAAAACTGCCCTGCCTGGGTTGACTCCTCTGGGGGTATAGACCGTGACCCTGGGTCTCCC TTCACCTCCAGGAGCTCATTGGTGCAACGGCAGGGAAGCTGCACACGGGACGGAGCCGGA ATGACCAGGTGCTTTAGCCCCTCCACCCCCTGCTCCGTGTTGTCCCAACCTTGAGGAGCC CAGGGGGCAGTTAGAGTTCTGCAGCGGTCCTGGCTCCTCAGGGAAGCAACACATCGGCCT CCCTGAGCACCATCTCCTCCTTGCACAGGTGGTCACAGACCTCAGGCTGTGGATGCGGCA GACCTGCTCCACGCTCTCGGGCCTCCTCTGGGAGCTCATTAGGACCATGGTGGATCGGGC AGAGGCGTGAGTCCTACAGGGACACCCAGGGGGCAGACAGAGGTGTGATGGAAGCCTGAA CAGGAGACCTAGGGGGCAGGGGTGAACAGCGTGGGGGTGCCAGGCCCTGGGGGACAGGGG CATCCCAGAACTCCAGGATCGAGGCAGAGCAGCCAGGAGTGGGCCATTTCCTGCAGGCCC CAATACTCCCATGCCAGTCTAGCTCAGCAGGCAGAGAAGACTAACCCTTCGTGGGGCTGG GTGCGGTGGCTCACGCCTGTAATCTCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCT GAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGGAAAACTCTGTCTCTACTAAAAAT ACAAAAATTAGGCAATGTGGTGGTGTGCGCCTGTAATCCCAGCTACTCGGGAGCCTGAGG CAGAAGAACTGCTTGAACCCGGGAGGAGGAGGTTGCAATGAGCCGAGATCGCGCCATTGC ACTCCAGCCTGGGCTACAGAGCGAGACTCCTGTCTCAAAAAAAAAGAAAAAAAAAAAAGA AAACTCACCATTTGCAGATTTGAAGGCAGGAAGCTAAGCCAAGCACAGCTAGCTTGGCTG TGCCTGGAGCAGCCAGAGTCACTCCCCACACTGCCTGTCCCCCAGATCCCCCATCCTAAG CTTCGCCTCCCCATCCAGCCCATCTGGCAAAAGACAGAGCCAAAGGCTGCCTCCTGCTGG CCTCATTTCAGGCTTTGGCTTCTGGGACCTGGTGTCTTTGGGACTGGATTTGTTCCTTGC AGACCTGGACGAAGAGCTGCTGAGAAGTCTCCATGTGTTGTCAGAGACCCCTCCTCTTCC TCAACTCCCTGTGACCCCTGTTGTGCAGACTTGGGGGAAAACAAGGGCACAAGAATTGTC ACCCAGCAGGTGGTGTGGGGCTGCTAGGAGGAACAGGGAGTGTCTGCTACTGAGTTCAGG GTTTCTTTAATTTTTTGTTGTTGTTGTTTGTTGTTGTTTTTTTTTTTTTGAGACAGGGTT TTGCTCTGTCACCTAGTCTGGAGTGTAGTGGCGCTATCTGAGCTAACTGCAAACTCTGCC TCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCCAAGTAGCTGAGATTACAGGTGTGC ACCACCATGTCCAGCTAATTTTTGTATTTTTTTCAGTAGAGATGGGTTTTGCCATGTTGA CCAGGCTGGTCTTGAACTCCTGAGCTCAGGTGATCTGCCCGCGTCGGCCTGCCAAAGTGC TAGGATTACACCCATAAGCCACTGCGCTCAGCTTAATTTTTAAATTTTTAACTTTTTAAA TTGTCTTTAGAGATGAGATCCTGCTCTGTCACCTAGGCTGGAGTGCAATGGCTTGGTAAT AGCTCACTGCAGTCTCAAACTCCTGGACTCAAATGATCCTCCCACCTCAGCTTTCTGAGT AGCTAGGACCACAGGTGTGCACCACCTGTGAGACAGAGTCTTGCTCTGTTGCCCAGGCTG GAGTGCAGTGGCGTGATCTCCACTCACTGCAACCTCTGCCTCCCAGGTTCACGCCATTCT CCTGCCTCAGCCTCCCGAGTAGCTGGGAGTACAGGTGCCCACCACCACGCCCGGCTAATT TTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCC GACCTCATGATCCACCCACCTCGGACTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACC GTGCCCAGCCGCGAATTCTTTAAATTTTTTGTAGAAACAGGGTCTCACTATGTGGCTCAG GCTGGTCTCAAACTCCCGGCCTTAAGTGATCCTTCCCTCTTGGCCTCCCAAAGTGCTGGG ATTAAAGACTTGAGCCACCGTGCCTGGCCTTGAGTACAGAATTTCTTCATGGGGTGATGA AAATGTTCTAAAATTGGTTGTGGTGATGGTTGTACAGTAAAGTGTAAACTTTAAATGAGT AAATTGTGAATGATATCTCAGTAAAGCTGGTTTATTTAAAACAACAGGCCAGGTGCTGTG GCTCACGCCTGTAATCCCAGCACTTTGGAAGGCTGAGGCGGGTGAATCACCTGAGGTCAA GAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACACAAAA TTAGCTGGGTGTGATGGTGGGCACCTGTAGTCCCAGCTACTTGGGAGGCAGGAGAATCTC TTGGACCTGGGAGGTGGAGGTTGTAGTGAGCCGAGATCACGCCACTGCATTCCAGCCTGG GCAACAAGAGCGAAACTCTTTCTCAAAAACAACAACAACAAAAAAACAGGCCAGGTATGG TGGCTCATATCTGTAATCCCAGCCCTTTGGGAGGCCAAGGCAGGAGGACTGCCTGAAACC AGGAGTTTCAGACCACTCTGGGCAACATAGCAAGACCCCATCTTTTTTTTTTTTTTTGAG ACGGAGTCTCGCTCTGTCGCCCAGGCTGAAGTGCAATGGTGCAATCTCAACTCACTGCAA GCTCTGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCCTCCTGAGTAGCTGGAACTA CAGGCGCCCACCACTACGCCCGGCTAATTTTTTGTATTTTTAGTATAGATGGGGTTTCAC CGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCGGCCTCCCA AAGTGCTGGGATTACAGGCGTGAGTTACCGCGCCTGGCCACAAGACCCCATCTTTACAAA AAACTAAAAATTAGCTGGGCATGGTGGCATGTCCCTTTAGTCCCAGCTACTCAGGAGGCT GAGACAGGAGGATCGCTTGAGCCCAGGAGATCGAGGCAGCAGTGAGCTATGATCATGCCA CTGCACTCCAGTCTGGGCAACAGAACGAGACCTTGTCTCTAAAAATAAAAACAAAACAAA ACAACAAGAAAACAGGACCATCACTCACAGCACCTCTGCCTCTGCCCTGCCTACTTGAAT GAGGTGCAGGGCATCTCACCTGCTCAGAGCAGCCCTTGAATGAGCCCCAGCTATTTCTAG GGTCCTCAAACGAAACCTCCCACGGCCAAGTCATACCCAACATGGGCCTCCTCCCCTATT CTGGCCCCTGCTCGGAGATGCTGAGTGACAGAGGCTGGACTTGGGGTGTTTCTGGCAAAG CCTCACTGCAGGAAGCCCCACAGCTCAGGCCCAGTCCTTGGTTCACACGGTCCCACTTCC AGCTTCTTTTGCCCTTAAGACTGATTTGTCCCTGGGAGATCACCAGATCCCTCATTCAGG TGGAGTGCTGCAGCGTGACACTTTTTCCAGGGGTGACCCAGGCCTGCAGGGTTCCAGTGT CACAGGCAGGCCTTGCATGAGCCTCCACCCGAGCTTCTGCTCCTCCTCTCCCACAGGGAA CGTGATGTTCTCTTCCCGGGGTACACCCATTTGCAGAGGGCCCAGCCCATCCGCTGGAGC CACTGGATTCTGAGGTGAGCCAGGTGAGGTGCAGGGGCTGTGCTAGAGGGGAGGACCCCG GCTGCCCTGACCCTCCTGCCCCTGGCTTCCCACAGCCACGCCGTGGCACTGACCCGAGAC TCTGAGCGGCTGCTGGAGGTGCGGAAGCGGATCAATGTCCTGCCCCTGGGGAGGTGGGTG AGGCTCCAGTGCCCCGAGGGCCTGGTGGGGGTGGCTGCTGCATAGCCTTAGGGATTGACA GAGCTGGGAAGTGCAGAGTGGGACAGAAAACCGCCTTATCTGCTCAGCGGGGGACTCTGC ATGGAGCCCCAGCTCTCGCTAAGGTGACGACCAAGCCATTGAATGTGTCTGAGCAGGGCC AGAGCCCTCCAGCAAGGCTCCTGGCAAGCCCAGCCTGCTGCCCTCAGCCTGACATGTGGG AACATGTGTCAGGAGACAAGTGTCCTGCACCCAGGGTGACTTAGTGCTTGGGGACAAGTG TTTTGTGGACACTTGGGGACAAGTATTCTGTACCCAAGGAGACTGGGCCAGGGAAGAGGC TAAGCGCCAGGTGGTTGCCCTGGCAACCAGGACTTGGTTCTCTGTGTGTGCGTTCGTGTG TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCAGGGCTGCCTGCCAGGAGCCCTGG TCACCATGAATCCCTGTCCCTGCAGTGGGGCCATTGCAGGCAATCCCCTGGGTGTGGACC GAGAGCTGCTCCGAGCAGGTGAGACGTCCTGCCCCTCCTCCCCAGGGAGAATCACCCTCA GCACCCGCCAAGACCTGCAGACACACCTGAAACCAGAGGGCAGGGGCCTGTGGCTCCTGG TGAAACCTTCATTCATTGCCTATGGGCACTGAGGTCATCAAGTTCAGGGGTCACTCATGG CAGGGATGCCTGGTACTGAGAGACTCAGGGCTCCTGCCTCCCTCCTGGGACTGTGCAAAA GATCCCTCCCCCCAGCTGTTGCCCCACCCTGATCAGGGGAGGGGGCTGGGCAACCTAGTT GGGGGAGAGGGGGCCACTCCCTGTCCTCCAGCTTAGCCCTGCTTCCTCCCACCCCCCCAG AACTCAACTTTGGGGCCATCACTCTCAACAGCATGGATGCCACTAGTGAGCGGGACTTTG TGGGTGAGTCCTGGGGAGCCAGTCCCCTGCCCTGTGCCTCACTTTAGTCCTTCAGCCCAG CTTCTCTCCAGTTTCCTCCCACACCTCCACGGACAGGCTGGTTGTGGTGATATTGTACAC TGAAGTATAAACCTTAAATGGGTAAAGTGGGTGGGGCATGGTGGTTCACCATGCCCAGCA CTGGCCAACATGGTGAAACCCCATCTCTACTAAGAATACAAAATTTAGCTGGGTGTGTGG TGGCAGGTGCCTGTAATCCCAGCTACTCAGGAGTTCTGAGGCCAGAGAATCACTTGAACC CAGGAGGCGGAGGCTGCAGTGAGCCAAGATCACGCCAGTGCACTCCAGCCTGGGCAACAA GAGCGAAACTCCATCTCAAAAAATAAAATAAAATAAAATAAAAATAAATAGGCCAGGCAT GGTGGCTCACGCCCGTAATCCTAGCACTTTGGGAGTCCGAGGCAGGTGGATCACATGAGG TCAGGAGTTTAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGCACAA AAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGAAG GAGATTCGCTGGAACCTGGGAGGTAGAGGTTGCAGTGAGCCAAGATTGTGCCACTGTACT CCAGCCTGTGCATTGGGAGCGAGACTCCATCTCAATAAATAAATAAATAAATAAATGGAT AAATTGTATGTGAGTGATAACTCAGTAAAGCTGGTTTATTTAAAACAACAACAATAACAA AAAACACGCTAGGTGCAATGGCTTACGTTTGTAATCCTAGCACTTTGGGAGGCCAAAGCA GAAGGATTGCTTGAGCCCACAAGTTTCAGAACAGCTTGGGCGACATAGCACGACCCCATC TTTGCGAAAAATGAAAATTTAGCCGGGTCCCCCCACCGCCTAACCTCCTCCTGCCCCCTG TATGGTCAGGCTGGGTGGGGATGGGAGAGGCCTGGTGACTGGGAACCTTTTCTCCCAGCC GAGTTCCTGTTCTGGGCTTCGCTGTGCATGACCCATCTCAGCAGGATGGCCGAGGACCTC ATCCTCTACTGCACCAAGGAATTCAGCTTCGTGCAGCTCTCAGATGCCTACAGGTAAGCC CTGAACTGCCACCTCCATCTGCCGCTGCCGGCCTCTGTATCCCCCGCCGCCCGCGGACGT GGCTGCCTTCCTCCCCGTCCCACCCCTCCGCCAGACCTGGCCATTGCGGCGCTGGACCAG CCAAGGGTCCAGCCCCTTCAGCGCCAGCACCTCTGTCCCCAGCACGGGAAGCAGCCTGAT GCCCCAGAAGAAAAACCCCGACAGTTTGGAGCTGATCCGGAGCAAGGCTGGGCGTGTGTT TGGGCGGGTGAGCAAGGCAGGGGGAGGGGCGGGGCCTCTGGGCTGATGGTGGGTGGCCAG GGGGGCAGGATCCCGGGTCCAGCCCCTGTGCCTCCCTCTTCCCGCAGTGTGCCGGGCTCC TGATGACCCTCAAGGGACTTCCCAGCACCTACAACAAAGACTTACAGGTGCGAGGCCGGG GGAGGCCTGGCTAGTACGTGCCAGTTCTCAGGGCTCTGGCACACTCAGGCAGGGCCCCAC CCCGGGATTGCCATACATCCTCCCATCCTGTGCACACAGCTCCATCCGTGGCTGCCCTTG AACTCTCTGCCCTTCCTTTGTTGGGGTATTGAGTGTTCTTCCCATGGAAGGCAGTGGGGA TGCCTCAGTGGGGGGGTGGGGCTGTGGGGACCCTGGGTGCCAGGGGGCTGCTAGGCCCTC ACCTCCTGCCATGTGCCTCCCAGGAGGACAAGGAAGCTGTGTTTGAAGTGTCAGACACTA TGAGTGCCGTGCTCCAGGTGGCCACTGGCGTCATCTCTACGCTGCAGGCAAGACATCACC CCCCTGCTTCTCCTCCCCTAGGTCCCAGGCACTGGGGTGGGCATGCGGGGAGGGTGGCCT TGGGAGGAGGTGAGGTGGGGCTGGAGGACCTGGGGCAGGGAAGGAGAGGTGTGCTCGCTC CTGCTCCTGGGGAACAGGGAAAGGACAGAAACTGCTGCCATGCAGTGGAAGTAGATGAGA CTCAGGGGGCCTGGGGCCTGTCAAATGGCCTGACCAGAACTCTTTAAAAAAAGAAAATCT AAACAAAAGGCCAGGTGCAGTGGCTCATGCCTGGAATCTCACACTTTGGGAGGCCGAGGC AGATGGAGCACTTGAGGTCAGGGGTTTGAGACCAGCCTGGCCAACATGGCGTAACCACGT CTCTACTAAAAATACAAAAATTAGCCAGGCGTGATGGCCCACACCTGTAATCCCAGCTAC TCAGGAGGCGGAGGCAGAAGAATAGCTTGAACCCAGGAGATGGAAGTTGTAGTGAGCCAA GATCATGCCGCTGCACTCCAGCCTGGACCACAGAGTAAAACTCCATCTACAAATATATAA ATTAAATTAAATTAAATTAAATATCTTTAAAAAACATTTTTTAGAGACAGGGTCACTCTC TGTCGCCCAGGCTGGAGTGCAGTGGTGCGGTCGTAGCTCACTGCAGCCTCAAACTCTTGG GCTCAAGTGATCTTCCCACCTCAGTCTCCAGAGTAGCTGGGACTACAAACATGCGCCACC ACGCCTGGCTAATTTTTTTATTTTTTGTAGAGACAGGGTCTCCCTATGTTTCCCAGGCTG GTCTCAAATTCCTGGCCCCAAGCCATCCTCCCACCTTGGTCTCCCAAGGTGCTGGGATTA TAGGCATGAGCCACTTTGCCTGGCTGATTTCTTTTAAAATCAATTATTATGGGAAATTTA TGTATATAACAGCTAGAGAATGCATAATGAACCCTATGTACCGACACCCAGCTTCAATGA TAATCAACTCACGGACATCCTGGCTCCAGCTGTCTTTACCCACAGCTCTCTCCCACTCCC TTACCCCCTTATTTTGAAGCAAATTCCCATCATCACATCATTTCATTCCTAAATAGTTCA GGATATGTCTTGAAATCAGTGTTTCTTGGCTGGGTGCAGAGCCTCATGCCTGTAATCCCA TCAATTTGCGAGACTAAGGTGGGCAGATCACTCGAGGTCAGGAGTTCGAGACCAGCCTGG CCAACATGGCGAAACCCCGTCTTTACTAAAAATATAAAAATTAGCTGGGTGTGGTGGTAC ACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGA TGGAGACTGCAGTGAGCAGAGATCACGCCACTGCGCTCCAGCCTGTGTGACAGTGCAAGA CTCCATCTCAAAAAAAAAAAAAAAAAAAAAAGGCAGTGTTTCTGGAGGCTAGTCCCCCAA CTAGCAGCACCAGCATCACCTCAGAAGTCCTGAGAAATGTGATGTGAGGCCCCACTCCAG ATGGCTGAATCAGAGACTCTGGGGGTGCTCCCCAGCAATTTGTATTTTTCTTAGTAAATT CTCCAGTGGCTAGGCCTGGTGGCTCATGCTTGTAATCCCAGCACTTTGAGAAGCTGAGGC AGGAGAAGCGCTTGAGCCCAGGAGTTCAAAACCAGCCTGAGCAACATAGCGAGACCTTGT CTGTAAAATTAAAAAAATTAAATTAGCCAGTCGTGATGGCGTGTACCTGTGGTCCCAGCC ACTTAGGAGACTGATGTGGGAGGATCCCTTGAGCCCAGGAGCTCAAGGATGCAGAGAGCC AGGATTGTGCCATTGCACTCCAACATGGGCGACCCTGTCTCAAAAAAGCCCAAAACAACA ACAACAAATTAGCTAGGCACGGTGGTGTGCATGGCTGTAGTCCCAGCTACTTGGGAGGCT GAGGCTGGAAGATCCCTTGAGTCCAGGCTGCAGAGGGCTATAATGGCCACTGCACTCCAG CCTGGACAACAGAGCAAGACCCTGTCTCCTAAAACAGAAAACAAATCCTCCAGGAACATC TGATGCATGCTGAAGATAAGGACTCTTTGAAAACATAAAGGCCAGTAAAACATACAGGCC AGTAAGTGTTCATAGCACATGTAAATATTATCGATAATTATGAGAAGATGGTTCAAGTTG AGAGTGAGACAGAGCCGAGTGGGTAAGAGAGTATCTGCCCAAGGCAGGGATGTCCTGGCA GAGGGGCAGGTCCTGGGCCTGGCAGCTTCAGATCCCAGGGTCCCCAGGGCTCACCACTCG CCCACCTGTGCCCCCAGATTCACCAAGAGAACATGGGACAGGCTCTCAGCCCCGACATGC TGGCCACTGACCTTGCCTATTACCTGGTCCGCAAAGGGGTAAGTGTGTAGCAGCCAGGGG GAGGGTGAGGAGATGGGGTGCCCCCCCCAGAGGGTGGGGGAGCTCAGGAATGGGTGCAAG CGGCCCAGCCTGGTGGCTCACCCCTGTAATCCCAGCACTTTGGGAAGCCGAGGTGGGCGG GTCACTTGAGGCCAGGAGTTCGAGACCAGCCTGGTCAACATGGTGAAACCCCGTCTCTTT TGATGTAAAAATACAACAATTAGCTGGGTGTGGTGGCACACTCCTGTAATCCCAGTTACT CGGGAGGCTGAGGCAGGAGAATTGATTGAACTGGGAGGTGGAGTTTGCGGTGAGGTGAGA TCGCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTTTGTGTCAAAAAGAAAAAAA AAAAAAAAAGGAAGGGGGTGCAGGCAATGGAGGCAGATCAGGGCATGGAGAAACCTGCCT CAGCGCCATCTTCCTCCCTGGCACCCAGATGCCATTCCGCCAGGCCCACGAGGCCTCCGG GAAAGCTGTGTTCATGGCCGAGACCAAGGGGGTCGCCCTCAACCAGCTGTCACTGCAGGA GCTGCAGACCATCAGGTACGGCCCATCCCCTTCCCCATGCTGCCTCCTAGGAAGTGAGCC TGGGTGCCTGGAGCCCAGGGTGGCCTGGCGCCCTGGCCCACCTCTTCCTCTCTCCCCAGC CCCCTGTTCTCGGGCGACGTGATCTGCGTGTGGGACTACGGGCACAGTGTGGAGCAGTAT GGTGCCCTGGGCGGCACTGCGCGCTCCAGCGTCGACTGGCAGATCCGCCAGGTGCGGGCG CTACTGCAGGCACAGCAGGCCTAGGTCCTCCCACACCTGCCCCCTAATAAAGTGGGCGCG AGAGGAGGCTGCTGTGTGTTTCCTGCCCCAGCCTGGCTCCCTCGTTGCTGGGCTTTCGGG GCTGGCCAGTGGGGACAGTCAGGGACTGGAGAGGCAGGGCAGGGTGGCCTGTAATCCCAG CACTTTGGAAGGGCAAGGTGCGAGGATGCTTGAGGCCAGGAGTTTGACACAGCCTGGGCA ACACAGGGAGACCCCCATCTCTACTCAATAATAAAACAAATAGCCTGGCGTGGTGGCCCA TGCATATAGTCCCAGCTACTTGTAAGGCTGAGGTGAGAGGACACTTGTGCCCAGGAGTGG AGGCTGCAGTGAGCTATGATCACGCCACTGCATTCCAGCCTGGATAACAGAGTGAGAACC TATCTCTAAAAATAAATAAATAAACGAAAAATAAA OMIM ID 608310