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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MRE11A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4361
Official gene symbolMRE11A
Full nameMRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Aliases,ATLD,HNGS1,MRE11,MRE11B,
Gene summaryThis gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q21
Gene position94227040 - 94150466  Map Viewer
Gene orientationminus
Gene size76575 bp
Gene sequence
OMIM ID600814