Entrez gene ID | | 4361 |
Official gene symbol | | MRE11A |
Full name | | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) |
Aliases | | ,ATLD,HNGS1,MRE11,MRE11B, |
Gene summary | | This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q21 |
Gene position | | 94227040 - 94150466 Map Viewer |
Gene orientation | | minus |
Gene size | | 76575 bp |
Gene sequence |
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OMIM ID | | 600814 |