Entrez gene ID | | 467 |
Official gene symbol | | ATF3 |
Full name | | activating transcription factor 3 |
Aliases | | ,-, |
Gene summary | | Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q32.3 |
Gene position | | 212738697 - 212794117 Map Viewer |
Gene orientation | | plus |
Gene size | | 55421 bp |
Gene sequence |
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