Entrez gene ID | | 4694 |
Official gene symbol | | NDUFA1 |
Full name | | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa |
Aliases | | ,CI-MWFE,MWFE,ZNF183, |
Gene summary | | The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xq24 |
Gene position | | 119005734 - 119010629 Map Viewer |
Gene orientation | | plus |
Gene size | | 4896 bp |
Gene sequence |
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OMIM ID | | 300078 |
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