Entrez gene ID | | 47 |
Official gene symbol | | ACLY |
Full name | | ATP citrate lyase |
Aliases | | ,ACL,ATPCL,CLATP, |
Gene summary | | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q12-q21 |
Gene position | | 40075272 - 40023179 Map Viewer |
Gene orientation | | minus |
Gene size | | 52094 bp |
Gene sequence |
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OMIM ID | | 108728 |
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