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Gene information for ACLY (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID47
Official gene symbolACLY
Full nameATP citrate lyase
Aliases,ACL,ATPCL,CLATP,
Gene summaryATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q12-q21
Gene position40075272 - 40023179  Map Viewer
Gene orientationminus
Gene size52094 bp
Gene sequence
OMIM ID108728