Entrez gene ID | | 4724 |
Official gene symbol | | NDUFS4 |
Full name | | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) |
Aliases | | ,AQDQ,CI-18, |
Gene summary | | This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q11.1 |
Gene position | | 52856465 - 52979171 Map Viewer |
Gene orientation | | plus |
Gene size | | 122707 bp |
Gene sequence |
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OMIM ID | | 602694 |
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