Entrez gene ID | | 477 |
Official gene symbol | | ATP1A2 |
Full name | | ATPase, Na+/K+ transporting, alpha 2 polypeptide |
Aliases | | ,FHM2,MGC59864,MHP2, |
Gene summary | | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q21-q23 |
Gene position | | 160085520 - 160113381 Map Viewer |
Gene orientation | | plus |
Gene size | | 27862 bp |
Gene sequence |
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OMIM ID | | 182340 |
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