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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NFKBIE (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4794 Official gene symbol NFKBIE Full name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon Aliases ,IKBE, Gene summary NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6, MIM 601512), AP1 (JUN, MIM 165160), and NFAT (see NFATC1, MIM 600489).[supplied by OMIM] Location Chromosome: 6   Locus: 6p21.1 Gene position 44233525 - 44225903  Map Viewer Gene orientation minus Gene size 7623 bp Gene sequence >NFKBIE:complement(44165903..44173525):Length=7623 AATGAATGAATGAATGAATGAGTGAATGAATCAACGAAGGAGTGAGTCAAGGCCCGGGAA CCACAGACTCCAAGCCTACGCAGAGCCCGGGAAGGGGGATTCCGGAGGGGCGGGGCCTCT TTCCGGAAGCGCCCGCCGGGGGCGGGGAGGGGGCGGGGCCATCCGCGTGAGGCGACCCTG TTGGTCCGGAGGGGCGGGGCGAGGAGGAGGACCCGCTTGGGCGGTTCGGCTGCCCACAGT AACCGCTGGGTGGACCTGGCCAGCGCTCCGAACCTTGTCCTCGCTGCGCGCCGGCCCCTC GGAGCCCCACAGCCCGGGAAGGAGGCCGCCGCGGGCCGGGCGCCCGCTCTGCCAAGCGGA CCCGCAACCCGGAAAGGCGGCGCGGCGGAGCCTGGAGCCGGATCCTGCTCAGACCGGGCC CCGGCCGGCCAGAGCCGCGGGCATGTCGGAGGCGCGGAAGGGGCCGGACGAGGCGGAGGA GAGCCAGTACGACTCTGGCATTGAGTCTCTGCGCTCTCTGCGCTCCCTACCCGAGTCCAC CTCGGCTCCAGCCTCCGGGCCCTCGGACGGCAGCCCCCAGCCCTGCACCCATCCTCCGGG ACCCGTCAAGGAACCACAGGAGAAGGAAGACGCGGATGGGGAGCGGGCTGATTCCACCTA TGGCTCCTCCTCGCTCACCTACACCCTGTCCTTGCTGGGGGGCCCCGAGGCTGAGGACCC GGCCCCACGCCTGCCACTCCCCCACGTGGGGGCGCTGAGCCCTCAGCAGCTGGAAGCACT CACTTACATCTCCGAGGACGGAGACACGTGAGTATGGGGGCTAGGCTGAATCGGGATGCT AACTCTGGGCCTGCCCAAGAGCCGCAACAGGTCGGGCACCCCCACTCCCCCGTGAAGATC CTTCAAGTCCCCATTCGCTCTTCCAAACTCCAGACTTAACTCTCAGCCCACTTTTGAGGT CCAGCTAGGCCATGGAATCATCTCTGTCCTCCCATTTCGGGGTGGGCAGAGCTGGCAGGA CCCTTAACCCAGCCAGCATCTTGGAAATCTACCAATAATCCACCCTTAGGAAGAGAAAAT TCCCCTGACCAAGTCCAGTTTTTTTGTTTCTTCTTGCTGGGGAAGGGGACATCCTTATTT GCTCAATATCTGGGATTCCCAGTTCCTGACCTCAGAATGCTCTGTCTCAAGGAACAACAG GTGCCAGTTACAGGTTGCCAGTCGGGGCCAGGAAGCTAGGCATGGGGGGTGCCACCAGGG TGTAGGTTTGGGACTGGTCCTCAGGAGGATGGGGTGAGCCAGGCTGGGGCACTCTTGCCC CAGCAGACAGACAGGCGGCTGGCTGCCCCAGCTTACTTCCTCCTCTGCTAAGAAAGGGGA AGTGAGGGCTAGAGTCAGCGTCCCTGACATCCTCTACCTCCAGAGCCCCCAGTCCCACTA ACTGTCGTGTCTCACTCCCTCACTTAACCCTTCCTCCTCCAGACCCAGATGGAGTTTGGT GGGAGTGGGCCAGAGGGCAGTTGAAGTAAAAGGCAGTTGTGTGGGATGGGTTGGCCAGTT GAGGATTTAGCCCCCCAGGAAGAAGAAAACATTGACAGAGGAGGGAAAGGTTGGGAACTG GGGATGAGAAATAGAGTTGGGGAGGGCTGGAATCCCTGGTCAAGGGTGCTCATATAAATA GGAGTAGGGGAGGCAGGAGGTGGCTGTCCTAACCTGCTTTTTGGAGATGCAGGGTCCTAA TCCTGGGTGGCCATTGATAAAGACAGCTGGTGGACCCAGTGGGTGGGAGAGGAGTGACCC AGTCCTTTCTGTACTCTGCCTGGATCACCAGCCCTCAGGCCCAGAACCCCAAGGTTTTGG GGGCTGCACGCAAGATACCTCTGATGACCTTTGATCCAAGGAGAGGGGACTTTTGACATT GCCGTCTTTTGTTAGCCTCTCAGCCCCAGCCTTTTCCATCTCTAGTTAGAAGCAGGTGTT GTGTCCAGATTGGGTGTGTGTGTGGAGGGGAGAAATGTCCGGGCTCCCCAGCGAGTCCCC AGAGAGCAGGGGGCACTTTCCTCCCTCTGTTGGAGGTGTCTGGGCTGTGGGAGGTATGGA AGTGGGAAGAGGAAGTGGGAGGAGGGGATACTGGGGGAGAGAGGGAGGTGGCTGCAAGAA TGTGACCCAGAGAGCAGGCCCTGGCCTAGGGGATTTCCAGAGCAGTTCCTCCCTCCCTCC GTCACTCTCCTGGGCCTCTCCTGCTGCCTGCTGCTAAAGCCTGCCACCCTCCTGCCCAAG CAGCCCCCTCCCCAGCCCAGACGGGCCTTTTAGCCAATCTACCCCCCTCACTAATGCCCC AAGGCAGCTGTCCCGGCCTAGACCCTCCATCACTGGCTTTCGTTTTCCCCACCTGACGTG GGGAAACCCCAAGACTGGAACTTCCCCTCCCAACTGCCCCCATTACCCCTAGATTAAGGT TCTTGGCCCCCTCAACAAATACATTTTCTGCACTACAAAGACCTCCTCTTGGAGGTGCAC ACAGGAATGGAGGGCCTCTGTTAGGCCCGACCTGGTCTGTGCTATCTGAGAGGTGCCTCT TGACTCCCAGGGAAGGGCAGCAGGACAGGATGCTGCACTGTCTCCTTGCTCCTCTTCCAA GAGTTTCTGTGTCTCTCCCTTGGAATGTGTAACACTGAGTTGCTTGGGGGTACGGGGTGA CCCTGCAACTGTCTCCTTCTTTCCTGTGTGCTGGGGTGGTGGGGTGCTTAGCCCTGGAAA CCCCCTCTGGACTACTTCGGCAGCTTTCAATTTGGCTTTGAGCTGCAGCTGGCTCGGCAG AGCCCTGAGGGCAAAGAGGAGTGGGTGTGGGCAGGCTGGACAGGAAGGCTGTTGTCCTGT CAGCACCCTGCCCACATGCCCACCCAGCCAAGGCCCTCCTGAAGGCCAGCAGTGGGAACT TGGAGCTCCAACCCTAGGATCCTGGCTTCCCACACCAACCCTCACTTCCTGGCCCACACT CTCACTTCCTGGACCTACCCTATGGGTAGCTAGTTAAAGTTTGATGTGTTCCTTCTAACT CCAAGACCCCAACCCACTCCCTCTGGCCTGGGCCCTTAACTCTAAGCCCCGCCTCTGCTC CCCTAGGCTGGTCCACCTGGCAGTGATTCATGAGGCCCCAGCGGTGCTGCTCTGTTGCCT GGCTTTGCTGCCCCAGGAGGTCCTGGACATTCAAAATAACCTTTACCAGGTTGGTGGCGA GAGAATGTTATGCCCAGATACCTGTTTGTGCCCTGGCAGCCATTCCCAGCAGCCATACCA GTCCAAAGGCTGCTCACTTAGGAAACCATATGCCAGACACTGAGCTAGAAACTGAGGAGA CAGACCCAAGTAAGACATGGCCTCTGTCCTGAGGTGCTTGCATCCTGGGCTGGGGGACTT GTATCAACAGCTAAATACACAGCCTGGTGACAAGAGTTGTGATAGAGACACATACCAGCT GCTATAGGGTCCAGTGTCTGTGTGCAGCAGCCAGGGAAGGCTTACAGAGGAGATGCCATC TGAATGGAGCCTAACAGAGAGTTTTGCCAGGGAGAGACTGCCCGGTGCCTCTATCTTTCC TCCTGCAGCCTAACCCCTGGGGGTAACAGAGGTCTCCTCACAGGGTGAGGGGCTAGACTC TCCTCCTACATGTCCTTTCTCCAGGGCCTAAGGTGACTTACAAGAAAAGCAGAGAGCTAC TTTCTTCACCTTGCTTCCAGAATTGGGATCCCAAGAGCTTGGTGGGGGAGGGGTGTGACA GGGGAAGGGCTCGGTAGTATTTCCTTGGAAGAACAGGTTATGGCCTTTATAAGCTGCTTT CAAAGAAGATGCTGGCAGCTGGTGATTCTTGAGCCCAAGCATGTTCCCAGAGGTGGGAGC ATGCTGCAGTGGCCCCATGACCCTCTATTTGTGCCTCCAGACAGCACTCCATCTGGCTGT ACATCTGGACCAACCGGGCGCAGTTCGGGCACTGGTGCTGAAGGGGGCCAGCCGGGCACT ACAGGACCGGCATGGTGACACAGCCCTTCATGTGGCCTGCCAGCGCCAGCACTTGGCCTG TGCCCGCTGCCTGCTGGAAGGGCGGCCAGAGCCAGGCAGAGGAACATCTCACTCTCTGGA CCTCCAGCTGCAAAACTGGCAAGGTGTGGACAGTCTTTAAGACTGCCCTTAGGGCCTGTG GGATGAGGAGGGCATAGGAGATAGGGACCTCACTCTTGGGGAAGGGAGGGTCCCAGCTTG TCCATTGGTGCCCCTCCCACTGTAAGCACATAGATATTCAGTACATCTTTGCCAAATGAA TGAATGGATGATTTGATTTCGAATTTAACCAGTACCTACTGCCTGCTGAGAAGAAAACTA AATCTTGCCCTTAAGATACTTAGTTTAATAGAGATTAGATGACCTGATTCATTCATTCAA CAGAAATGTACTGAGGGTTTTCTATGTGCCAGACGTTATCCTAGGAGCTACACTTGCATC TGTGTGCAAAATAGAGAAAGATTGAGATGAGCAATAAATGTAAGAAGTGAACTATGTAAT ATGTTAAAAGGAAGTAAGTGCTGTAGTAAAAAGCAGAGCAGAGTGAGAGGAAGGAATGTG GGGAGTAGGAGAGTTGATATGATTGTTAAATAGGGTGGTCCGGGAAGGCCTCATGGAGCC AGTGACATCTGAATAGCGCCCTGAGGAAGGTGAAGAATGTAAATTTGAATCGAAATCTCT ATTACTAAGCAAGGGTCGGGAGTGTCCAGACTAGAAAGGAGAGCAAAAAGGCCAGGGGAG CACAGAAGGAAGCGGCCCCTGAGAAAGGGCTGGGGGCATGAGGATCTTAGGTGGCTTTTC AGAAAAGGTGGCTTTCAGACTGGGCTTGAAGGCAGGTTGTGTGTGTGTGTGTGTGTGTGT GTGTGTGTCTGTATGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTAGTTTGTGTATAGGA GGAGGGTGTTCTTTGGGGGTGTCACTCAGCAGCCTGACCCCTGAAGCATGAAAGTTTCAA TAACATGACTCTGAAAAGGTGGAAACTTTGAGTTCCTTTCCCCTTAGACTTTTGAGGGGG TTTTGGGGTTTGCATTTTAACAGTCTTGTGATTAGAGACATTGAGTGGGCTGTGAGTCCC TTGGGGCTGAGTGGTAGGGAGGTCCCAGAAGAGAGGGAGTTGGTGGATGCAGATCAGCAG CCCTCACCCTCACTCTCACCCCATCCCAGGTCTGGCTTGTCTCCACATTGCCACCCTTCA GAAGAACCAACCACTCATGGAATTGCTGCTTCGGAATGGAGCTGACATTGATGTGCAGGT GAGACAGCCAGCAAAGCACTGCCCGGCCCAGGGCCTGCCCCCACCTGACACATCCCCAAG TCCCCTGCCCAGCAGTCAGAAGTGGTGGCATTCACTTCCTTATCCAGAGCCCAGGCCCAG CACACTGCCTCTGAGGGCCTTGGCTGACATCCTTATTCCTCCCCAGGAGGGCACCAGTGG TAAGACAGCGCTGCACCTGGCTGTGGAAACCCAAGAGCGGGGCCTGGTACAGTTCCTGCT CCAGGCTGGTGCCCAGGTAGATGCCCGCATGCTGAACGGGTGCACACCCCTGCACCTGGC AGCTGGCCGGGGTCTCATGGGCATCTCATCCACTCTGTGCAAGGCGGGTGCTGACTCCCT GCTGCGGAATGTGGAGGATGAGACGCCCCAGGACCTGACTGAGGAAGTAAGTGGCATATG CTTTGCTCTCCAGGGCCTTGCACACCCATAGCAGAGAGAGGTTCTGTCATTAGCTGAAAG GGCCAGGGAGCCAGGAGTCCTGGGGTATAACCAGGACTCTGCCACTGACCAACTGTGGGA ACTTGAGCCTGTTTCCTTAGTTGGTCCAAGGAGCCAAATTTGGACTCTTACAGGGACCCT GCAGTTAAAGTGAATCAGTGAAGTTGGCCAGATATGAGACCATGGTGTGGTGAGGCCTAT AAGAACCCAGAGAGCCATCCCTGAGGGTCTCTGTACTCAGCTTCAGCAAAGGCTTACAAA GCAGGAGTGTAGGCCCAGTTTTTCCTGGTCTTGGACTTTCTTGAGAGGTGAAACTCAGAT TTTCTGTACAGTCTTTCCTATTTTTAAATGTTCAGTGTAAAAAAGAAACCTAAATGTTCT GCGAGTACCCAGCAGCCCCCCCACCCCATCCCCCAACAACAACAAACAACTCCAGGTCCA TGGGCTGGATCACCTCTAAGGGTCCCTCCTAACTCGGATATTCTGGCATTATCTTAGAAA AGGAAGGCTTGTCTAAGTCCTCAGGGCTCTGCCAAGCCCAGAGGGGCCACTATTTTGAGG ATTCGTGTGAAGATTTGTTCCCTGATGGTCTTCAACTGTCATTTGGTGGGGAGGGAGTGG CCCAACAGGTTTCCCTGGGTCCCCTTTCCCAAGTCACCTTTTCCCATGTCCTCTGATCTT GCTTCTCTCCATTCTCCTTCTCAGTCCCTTGTCCTTTTGCCCTTTGATGACCTGAAGATC TCAGGGAAACTGCTGCTGTGTACCGACTGAAGCCAGGCAGGGTCTGGGATCCTCAGGGCT CCACCTCTCCATCTGGAAGCCGGAGCCATAACTGCTGCAGTTTGGGCCCAGGCTATGTGC TCTTCTGGTGCCCTAGGGACTGCTGTGGCCAGAGCCTGGGGCCAGCCAGTACAGTCCTGA GCCGAGGAGGAGGGACTGCAAGTGGAAGAGAGCCAGTCTGGAAGGAAGAGCTTTCCAGGT GGACAGGGCTTCTTGGAAGACCCCCAAAGCCCCAGGTATCCTGGGTGAAGCCTGTTTGCC TCTCTTGAAAATGGCAGGTGCTCTTGTTTTACCCATGTTGGGTCAGCCTGAAACTGCCAA CCAGTAGGAAGCATGGACTCTCCTGAGTGAGAAGAGACTGAAATAGGAGCAAGCAGAACC CTGAGAGGTGTCCCATCTTATTGCTGTTGAGGACCCTGAAACACCGTTGTTTAAAGACTT CACACAGAAGGCTCTGAACTGAGCCACTGGGGAAGGGAAGTTTCAGTAACATGACACTAA AATGGCAGAGACGTTAAAAAAAGTTTTTCCCTTCTAGAGCTGTTTTGCGCGCATGCATGT CTGTGTGCATTGGGGCTTTTTAGACAGGCCTGCCCTGTGACTTTGTGGTAGAGGCAGAGA GAAGGAAATTGTCCCCTGAGCACGGTAGGGCCTTGCTGGGTGGGGTCAGAGGCCAGTAGT TCCAGGCCTTTCTCTGTGTCCAGCACAGACCCTTGTCCTTGCTGTGGAAATGATGAGGGA TGGAGGGACAAGAGGAAGAATGAGAGGACACACGCCCTGGAGCCCTCACCACTGCCCTGG GGGTTGCCATCTGGAGGAGCCTGGGGATAAGGGTAACCCAGGGAGGCTGGGCACGAGGGA GCTGACTCCACGTTTTTCCCCCCGTTCCTCACCTTCGAGGGCCCTGCTAGGTCACCCCTA TGCTGGCATGAAGAGCATGGGGCAATAAACCAGCACAGTCTCTGACCACTTGGAGCGTCT CATCCAGTGAGAGAGACAGCCGTTAAAAGCATAAACATCCAAATAAAGATGCCTTTCCAA GTT OMIM ID 604548