Entrez gene ID | | 481 |
Official gene symbol | | ATP1B1 |
Full name | | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | | ,ATP1B,MGC1798, |
Gene summary | | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q24 |
Gene position | | 169075947 - 169101960 Map Viewer |
Gene orientation | | plus |
Gene size | | 26014 bp |
Gene sequence |
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OMIM ID | | 182330 |
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