Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FXYD2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 486 Official gene symbol FXYD2 Full name FXYD domain containing ion transport regulator 2 Aliases ,ATP1G1,HOMG2,MGC12372, Gene summary This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: 11   Locus: 11q23 Gene position 117698807 - 117690790  Map Viewer Gene orientation minus Gene size 8018 bp Gene sequence >FXYD2:complement(21253206..21261223):Length=8018 GCCACTCTCCATCCAGGCCCCAGGCAAGCAGCACCTCCCTGCTCTCCTGCACTCCTGGAC ACAACCAGCAGCTCCTGCCATGGACAGGTGGTACCTGGGTGAGTCCTCTGAGCCCCATTC CTCCTCCCTGCTCAGGCTCTAACACAGGTGCCAGCCCCGTCCCTTTCAAGTGCACCCACA AGCTCCCCAGAAGTGCAGGAAAAGCAGAAAGGAAGAGAGGCAGAATTTCCAAAAAAGAGC ATCTCCATACGGAGTCACTGGCCTGCTGTAACGTGTGTGCAGAGCATATCTGAGCTGCGA GGGCTGGGAAGGCAGCTGTCCAACTGCCTCATTTACTTGTCTGTCCATCCGTCCCTTAGA GATGCAGGAACTCAGAAGCCAGGCTGCTGGCTTGAAATCTTGGTTCCCCTACCCTCTGGC CATCTGACCTCTGGCAAGTTATTTAACTTATCTGGGCCTCAGTTTCTTCCTCTATGAAAT GGGGTGATAATAATGCCTTCTTTACCTTCTAAAACTCATTGTGATGACTAAAGAATTAAT TTCTGGCCAGGCATGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGCGGG CGGATTATCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTC TACTAAAAATACAAAACTAGCCAGGCTTGGTGGCACATGCCTTTAATCCCAGCTACTCAG GAGGCTGAGACAGGAGAGTCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGTCGAGATC GCACCATTGCACTCCAGCCTGGGTGACAAGAGCGAAACTCCGTCTTAAAAAAAAGAATTA ATTTCTGTAAAGTGCTTGAAACGGTGCCTTGCACACAGAGTTTAAAAATGTAGCCATCAA CTAGCTTTCCCTATTGCTTCCTATTCATCTATCTATTGATCGATCTATCATCCATATCTA TCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTCTCTATTTATCTA TCTATCCATCCATCTGTTGGTGCCTCCCCATGCACCTCCTCCCCCCCGCAGTGGGAGCCC TTCCATCCACACTGCAGCTTTGTTTGTGACCAGGGTAAATATTACCTGGCACTGTTAATG TTTAATGCCCCCACCTCATCCCCAGCCACCCCACCAAGGAGCAAAGACAGCAGGAAGAGG CAAGTGGAGACAGTCCATTTGGGTGGGGAAATGACTGGGTTGTCAATGGATAGATAGATA GATAGACAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGACAGACA GACAGACAGACAGACAGATGAATTTATTTAACTTCCCACTTATTTTTACATCTCTTATTA TTCCCGAAAGACTCCATGGAGGCTTACAAATACAGACCAAATGCAATAAGATAACACAAT CCTGTATAATAAAGGGAGCACCCTTGTCTTGTGTGGAGATGGCAGTAGCTTTGGTAGCAC ATCTTGGAGGATCTGGGCTTTCTACCTCCAGTTTGCCATTAACTGTGTGTTTCAGGCAAG TCCCTTCACCTTCCTGCCCTCGTTTTTTCTGGTGTACCCAGTGCCCTGGCCACGTCCAGG GGCTATTGTGGAAAGCAAATGAGCAGCCTCAAGTTTCTTTATCTGTAAAACGCCATTAGT AGGAATTAAGTGATGCAGTGCATTCCAAGAGCCTGGCACGTGGTCCATCTTCACCAAACG CTGGCTCTGCTGTGATGTTTGCACGAATATATATTTCTTGGCTCCAGAAGCAGAAGGGAG CTGAACGGGTATTGCAGCGCCTGATCTGCAGGGCCATGCCATTCTCTCCGTCTCACTCAT TCGTGCCCATTTTCATTGGAGGGTGGCTGGCTTTTCCATGTCCAACAGCAAACATTTGCC AAAGGCTAATGCTTGTCATTTCTTCAATCAACACACATATAACAGTAAAAATGATGCCAC TCACCGTGTGCCAGGCCCTGGGATATGCTCTTTGCATGCATTATCTCACTTCCCCTCACC ACCACCCTAGGAGCTGGGTACTGCGCCCATTTTACAGATGAGGAGACTGAGGCACAGAGA GGTGAAGTCATTGACTGAGACCACACCATTAGCAAGTGAGAGGGCCAGGGTGTGAACTCA AGTGCCAAGCCCTGCCCCTGCTTGGGGAGGATTCATGGATACAGTGGCTCCCTTCAGAAG GGCTCAAGCTCCCCTGCTGTCCGCTGGCCACTGACCTTGGCTGTTTTGTGGCCATTGGGC TTCAGCCTTTTCTGGAGGCCAATTCAATGGACTAGAACTCAACGAGGATTCTACAGTACC TGTGACTACCCGGCACAGGAGTCCTGGGGCGAAGGAGGTCACAGCGGAGTGGGGAGGCTG CCTGCGAGGTGTGGAAAGCATCTGCCTCCTGCAGCAGGAGGCCTGATTGTCAGTCTCCAC TTCCCCCACACTGGCTGTGTGACCCTGGGCAAGGCCCCTACCTCTCTGTGCCTTAGACAC CTGCCTCATCAGTAAAATGGGAAACATAAAGCTTGAGGAGAAAAAACAGTGAGGAAAGTG CTTGGTAAACCATAAACGCAGGGGGTTTTCCCCACGATGAAAGTCTTGCCCTGTCCTTAA GGATCCTGCATGCTCCATGGTAAACTGGCAAGGACACAATCCGAGAGCCAGGCCAAATGG TGGTAGGAGGAAGTGCCAGGGCGGCAGGGAAGGAGAAATTAGTTGGGGATGACTGAAGCC CTTCTGAATGAGGTGTAACCTGCAGGGTGCACGTTGATGGGTGAATAGGATGACAGATGA AGGGCCCTTCTGGAGGATCTACTGCTGGTCAGCTTTGGCGGTGCTCCAGGGATGTGGTGG GGGAGCAGTGGGCCAGGCTCCTAGGGACCACTGCAGGAAAGCCTCCAGTACCACATAAGG AACACCAGCTGCAGCGGCGGCATCCATGGTGGCTGGTGCGGTGGGCCCTGCCTGGGCTGG GGGCCACTGTGGGCCACTGCCCCCAGAAACTCCCAAGTACAGTGTACACTGAAGAGATTG TGCAACTTCCACTTTCCTGTTCCCACCGCCCCAGCTGTAGCTTCCCCAGCTGGCAGAACA GCACGACTGCTGACCCATCCCAACCCTTCTCTTTGGAAATTTCCTTTGGGAAGGTTTGGA AACTCAGCCAGCTCCTCCCTGCCCCTGCCTCCCCACGCACGTCCTCACCCTGCAGAAGGA GCCCCTCCATCCACACTGCAGCTTTTCTTGTGACCAGGGTAAATATTACCTGGCACTGTT AATGTTTAATGCCCGCACCTCGTCCCCGGCCACCCCGTGGAGGCAGCCAGACACTCTCCA AAAAGCAGAGACAGCAGGAAGAGGGGAGTGGAGGCAGCCCATTCACCTGGGGAAATGACT GGGTTGTCGATGGACGGTGGTGAGTGTGCTGGTGTGCGTGCCCGGGCGTGTGCAATGCTG GGTGGCTCTGATTGGCCTGCCTTTGTGGGGTCAGCTGGACCCTACTCTTCCCTCTCCTGC CACCTCAGCCTTCCAGAGTACCCAGCCCCTCTTCCTGTCGGCCTCCTCTCTAAGAAAATT TGCAACTTAAAGGAGGACCCTGCTTTAACCCCAAAGAAAGATAGCTTGAGTGGCAGAAAG GCAGCAGATAGAAGCTGGAGAGCTGAGCGTTCCTCCTCGGCCTCCTGGCACACACCCGCC CTGAGTTCAATGCATCTTGCTAGACCGTCTGAACTTGGGCGGGAGGCAGACGGCGTCCAT CTGGCTGGGGAAGGAGCAGGCCCCTCTGGTCAGCCTTCCTAGGCTGGATTTGGGGTGAGA GCCCGCCAAGTTCAAGTCACACTCTCCAAAGGCTTCCTGTCACAGGAACTGACTCAGGCC TGGAAACCAAGAGGGGCACTTGCTGACAGAGGTGGGTTTTGAGCCAGATGCAGAAAGGGG AGGGTGCTGGGCAGGGAGGGTCTCAGCAAGCGGCTCAGGGCCAGGTGGCCACGGAGGAGG AGGTTTCCTGGGGCGTGTGGGGAAGCCTCAGCTGGCGTCTAGCTGTTGCTCTGACACTTA AATCCCCATATGACCTTAAACAAGGCCTGAACCAAATCTGGGAAGACAGCCCTGACGGCC TTCTGTGTGGGACCTGGGTCCTTCATGGCCTCCCTGAGCACCCAGCACCTCAGGCCCGTC AGGATGGGCACTGACTCTTCCTGGCCTGTCCTTTCCTGGCCCAGGGACTGGCCGCTGGGG ACAGCTGGGCTTGACAGACCCTAAGTCTCACTGCTGCTCAGGGGCACAGTTTGGCACAGC CCGGAAAGTGCTAACTTGCGCGTTCCTTCCTCCTCGGGCTCCACTTCCCTCGTGCGAGAA GGGGCTCCGGCAGGGCAGGAAAGAGTAGCGGCCCTTAGCTGTGGCAGAAGCGTCCTGGCC AGGCCACCGTCTGGCTGTCCGGGGCAAGTGTACTCAGTTGCAGGGCACCACTGTGAGACC TGCCTGCTGAGCGGCTCCAAATCCGGGGGAGGCCACCAGAGGCAGGGGCAGGACCTTACC TCTAACGGGCTCCTTCCCTCCCGCCATTGAGAGGTGGCAGATCAAAGGGCTTATGCACCT CCATTCTCAGCCCCCTGCTTCCTGGGTTCAAACACCAGCTCTACCCCTGACTTGCTGTAT AACTGTGGGGGAATTTCTTCTCTGCACTTCCACCCTCTTGTGGATTACACCAGAATGACA TTGACGCCTCATAAGGTTGCCATAATGGTTAGATGAGTTAGGGTTTGTTAGTTTTTGCCC GGTGCCTGACCAGCACTATATATTAATGTTTCTTAACTAGATCTGCTTCCCCTGAGGATG GTAACGCAGGAAAGGAGGTCTGTCTCAGCTTTCATTAGGACTTTGAACAAGTCTACACAT TGGGCTCGGCTTCCTCCTTCTGTCTGATAAACTTTAAGGTTCTGTTTTATTTATTCATGC ATTTCCCAAATAGCTGCTAAGCACCTGATAGCCAAATGGTCCTGTGGAGAGAGGCCGCTG GGAGTCTAATGGGAGAGGCTTCTCCTGGCCTTTTCTACCATGGTAGGAATCAAGGAGCAG GAGAGAGCCACCCTTCCGGAGTGGTCAGAGGCCCCCCAGACAGCACGGATCCCCCTCGGA CACTCGGTATTTGGTCCCCAGTTGAGCGTGTCTGAAGCCGCCTGGAGCAGAAGCCTGCTG GCAATGGTTTTAGCAACACCCCTGCTCCCAGCCTCCCCTCGCCTGCTTGGACCCTCGAGG GTCCTCTGGGAAGGGAAGGACAGGGAATTCCAGCTGTTCCTGTGGCTGGCTCACCATCGG TGACTCCTCTCATCCCACCTCTGGCTCTCTCCTAGGCGGCAGCCCCAAGGGGGACGTGGA CCCGTTCTACTATGGTAAGCCTGGGCCCCTGCGCACCCTTCCTGAGCCCTCAGGACCCCT TCCACCAAGCAGCGGCCTCTCCCAGCCCCAGGTCCATGCTCTGTGCCCCTTATCTCCCCT GGTTACCACGGGCTGCTGCGGGCAGGCTGCGGAGAGAGACAGCTGCTGGGAGAGACCACC CATCCCGCTCCTCTTGCCCTCTCTTTCCGGAGACTATGAGACCGTTCGCAATGGGGGCCT GATCTTCGCTGGACTGGCCTTCATCGTGGGGCTCCTCATCCTCCTCAGTAAGTGGGGTGG CCTCCAGGGAAGGGGTGCTGACCAGGGCACCTCTCTTCTCAAGGCCGCTGAGCAGGCTGG CTTTCGGGAGTTGCCAAGGGAGGGGTGAGCCTCCCCACCACGCCCCCCACTGCAGGATGT GGGAATGGGTGCCCGGTGGGGTGCCAGGCTCGCTGGGAGCACAGTGTGAGGTTCCTGCTT GCTCAAGTGCACCCTCCAGTGGGCCCGGGAGGAGCCGCAGAAGTGAGAGCAAACCCACGG GGTAACTGGGTAACCGGAGGGCCAGACAGGGGGACTAGGCCCCCCGCTGCTAACCATGGT CCCAAACTCATTTGTTAAATAGGGATGATCCCACCTGCCTCACAAGATTAGGGCTAGCAT CCAAAGACATGGCAGTCAGGACAGCGCTCTGAGAACGGTCCAGTGCAGACTCGGAGTGTT CTGGGGGAGACAAAGAGAGTTATGTATCCTCAAGCCCCGAGGGGCACACAGCAGGAGCTT AATAACTGCACATTGACTTGTTTTGGTCCAACCCAAAGAAAAATACACAGAAAACACAAC CCATGGAAAGAAGATACAGCAAGCACACCTGTGGGCTCTGGACTTCTAATGCACGTGTGC CACTGCCACCCCACCCCAAGGCTCGGGCCACAGTCCTGCGGGTCTCCCCATTTTCCCGTG TTGCCCATGGCAGCTCTCTCTACGTGTGCCACTGCCAGCCCACCCCAAGGCTCGGGCCAC AGTCCTGCAGGTCTCCCCATTTTCACATGTTGCCCGTGGCAGCTCCCGGAGGGCAGTGCC GGGTGGCAGCTGATCACATAGGCACAGGAGGCAGGTGGCCTAAGCAAGGGGCTCCACTTT GGAGTTGCTGCCATCCTTCTCCAGGTGTTCATCGGGCAGCTGTGCTGGGGGCACCATGAT GGCCCAGTCTCTGCTGCTACTCTCGATATGCCAACAGACCACCGTGGATCTGCTCCAGTA AATATTTGCTGACTGACTGACTGACTTAGGTTCTTAAATGCCTATGGTCCAGCCTTATAT AAAGAGAGAGAAGGCTGGGCGTGGTGGCTCATGCCTGTAATGCCGGCATATTAGGAGGCC AAGGCAGGAGGATCTCTTGAGACCAGGAGTTTAAGACCAGCCTGGTCAATACAGTGAGAC CCGATCTATACAAAAAAAAATTTTTTTAATTAGCTGGGCATGGTGACATGTACCTATAGT CCCAGCTACTTGGGAGGCTGAGGCAGGAGGATTACTTGAGCCCAGGAGTTTGAGGCTGCA GTGAGCTACGATCCCACCACTGCACTCCAGCCTGGGTGACAGAGTAAGACCCCGTCTCAA AAAATAAAATAAAATAAAATATAAAATAAAATAGAGACAGTCAAACGTGGCCTCCAAGCC TGACCCTGCGATGATACTGGCAGGAGGGAGGTAGGAGAGACTGGAAGAATTTTGAGTCTT CCAGGGTCTCCTTGGAAAATTAGTCCATGGAAACAAATCTCCTTTTCTCTTTTCAAGGCA GAAGATTCCGCTGTGGGGGCAATAAGAAGCGCAGGTGAGCGCTGCCTGGGGTGACCGATG AGGGGGTTGGGGCTGGAGAAGGAGGGGCGGGCTGAGGATTTTGTCTCTGACACAGTGGAG GATCCCCAGCCTCAGAGATCCCTAGACCCACCCCTCCCCCTGCCCTCTCACCTGTTGCTT TTCCTTCCCCCACCAGGCAAATCAATGAAGATGAGCCGTAACAGCAGGTATGCTAGGAGG GCCTGGGGAAGGTGCGGGGAGGGCAGGGCAGGCTTGGGAGCAACAGGGAAGAATTCTGGC TCCTGGACTCGGTAAATAAGAATTTTAGGGTCGTCCACACATCAGCCAGGTGGTCTGTCA CCCATCGTGTGTTTAAAATGATGGCCAAGGGCCTGGCGTGGAGTGTGTGCCGCAGGAGAT CACAGAGGAGCCCTGGAGAAAAGTGAGATGGACAAGGGGGAAGTAAAACCCCAACCTCTG CTGCCTCCCACCCAACCCCATCCTGCCTTTGTCTTCTCAGCCTCGGCGGTGCCACCCACT GCACTGGGGCCAGCTGGGAAGCCAAGCATGGCCCTGCCTCTGGCGCCTCCCCTTCTTCCC TGGGCTTTAGACCTTTGTCCCCGTCACTGCCAGCGCTTGGGCTGAAGGAAGCTCCAGACT CAATGTGACCCCCAGGTGGCATCGCCAACTCCTGCCTCGTGCCACCTCATGCTTATAATA AAGCCGGCGTCAGAGACCGCTGCTTCCCTCACCTGCCTGCCTGTCTCCCTCCTCTGTCAC CACCAGCCTCTCCAAGCTCAAGTACAAATACAGCCGGG OMIM ID 601814