Entrez gene ID | | 487 |
Official gene symbol | | ATP2A1 |
Full name | | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 |
Aliases | | ,ATP2A,SERCA1, |
Gene summary | | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16p12.1 |
Gene position | | 28889809 - 28915830 Map Viewer |
Gene orientation | | plus |
Gene size | | 26022 bp |
Gene sequence |
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OMIM ID | | 108730 |
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