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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NPPB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4879 Official gene symbol NPPB Full name natriuretic peptide precursor B Aliases ,BNP, Gene summary This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq] Location Chromosome: 1   Locus: 1p36.2 Gene position 11918992 - 11917521  Map Viewer Gene orientation minus Gene size 1472 bp Gene sequence >NPPB:complement(7922253..7923724):Length=1472 CCCCGCAGGCTGAGGGCAGGTGGGAAGCAAACCCGGACGCATCGCAGCAGCAGCAGCAGC AGCAGAAGCAGCAGCAGCAGCCTCCGCAGTCCCTCCAGAGACATGGATCCCCAGACAGCA CCTTCCCGGGCGCTCCTGCTCCTGCTCTTCTTGCATCTGGCTTTCCTGGGAGGTCGTTCC CACCCGCTGGGCAGCCCCGGTTCAGCCTCGGACTTGGAAACGTCCGGGTTACAGGTGAGA GCGGAGGGCAGCTCAGGGGGATTGGACAGCAGCAATGAAAGGGTCCTCACCTGCTGTCCC AAGAGGCCCTCATCTTTCCTTTGGAATTAGTGATAAAGGAATCAGAAAATGGAGAGACTG GGTGCCCTGACCCTGTACCCAAGGCAGTCGGTTCACTTGGGTGCCATGAAGGGCTGGTGA GCCCAGGGGTGGGTCCCTGAGGCTTGGACGCCCCCATTCATTGCAGGAGCAGCGCAACCA TTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAGCAGACATCCCTGGAGCCCCTCCAGGA GAGCCCCCGTCCCACAGGTGTCTGGAAGTCCCGGGAGGTAGCCACCGAGGGCATCCGTGG GCACCGCAAAATGGTCCTCTACACCCTGCGGGCACCACGAAGCCCCAAGATGGTGCAAGG GTCTGGCTGCTTTGGGAGGAAGATGGACCGGATCAGCTCCTCCAGTGGCCTGGGCTGCAA AGGTAAGCACCCCCTGCCACCCCGGCCGCCTTCCCCCATTCCAGTGTGTGACACTGTTAG AGTCACTTTGGGGTTTGTTGTCTCTGGGAACCACACTCTTTGAGAAAAGGTCACCTGGAC ATCGCTTCCTCTTGTTAACAGCCTTCAGGGCCAAGGGGTGCCTTTGTGGAATTAGTAAAT GTGGGCTTATTTCATTACCATGCCCACAATACCTTCTCCCCACCTCCTACTTCTTATCAA AGGGGCAGAATCTCCTTTGGGGGTCTGTTTATCATTTGGCAGCCCCCCAGTGGTGCAGAA AGAGAACCAAACATTTCCTCCTGGTTTCCTCTAAACTGTCTATAGTCTCAAAGGCAGAGA GCAGGATCACCAGAGCAATGATAATCCCCAATTTACAGATGAGGAAACTGAGGCTCAGAG AGTTGCATTAAGCCTCAAACGTCTGATGACTAACAGGGTGGTGGGTGGCACACGATGAGG TAAGCTCAGCCCCTGCCTCCATCTCCCACCCTAACCATCATCACCCTCTCTCTTTCCCTG ACAGTGCTGAGGCGGCATTAAGAGGAAGTCCTGGCTGCAGACACCTGCTTCTGATTCCAC AAGGGGCTTTTTCCTCAACCCTGTGGCCGCCTTTGAAGTGACTCATTTTTTTAATGTATT TATGTATTTATTTGATTGTTTTATATAAGATGGTTTCTTACCTTTGAGCACAAAATTTCC ACGGTGAAATAAAGTCAACATTATAAGCTTTA OMIM ID 600295