Entrez gene ID | | 4882 |
Official gene symbol | | NPR2 |
Full name | | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) |
Aliases | | ,AMDM,ANPRB,ANPb,GUC2B,GUCY2B,NPRB,NPRBi, |
Gene summary | | This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9p21-p12 |
Gene position | | 35792406 - 35809728 Map Viewer |
Gene orientation | | plus |
Gene size | | 17323 bp |
Gene sequence |
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OMIM ID | | 108961 |
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