Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ATP2B2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID491
Official gene symbolATP2B2
Full nameATPase, Ca++ transporting, plasma membrane 2
Aliases,PMCA2,PMCA2a,PMCA2i,
Gene summaryThe protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p25.3
Gene position10547268 - 10365707  Map Viewer
Gene orientationminus
Gene size181562 bp
Gene sequence
OMIM ID108733