Entrez gene ID | | 4938 |
Official gene symbol | | OAS1 |
Full name | | 2',5'-oligoadenylate synthetase 1, 40/46kDa |
Aliases | | ,IFI-4,OIAS,OIASI, |
Gene summary | | This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q24.1 |
Gene position | | 113344739 - 113357712 Map Viewer |
Gene orientation | | plus |
Gene size | | 12974 bp |
Gene sequence |
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OMIM ID | | 164350 |
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