Entrez gene ID | | 4968 |
Official gene symbol | | OGG1 |
Full name | | 8-oxoguanine DNA glycosylase |
Aliases | | ,HMMH,HOGG1,MUTM,OGH1, |
Gene summary | | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p26.2 |
Gene position | | 9791628 - 9808353 Map Viewer |
Gene orientation | | plus |
Gene size | | 16726 bp |
Gene sequence |
| |
OMIM ID | | 601982 |
|