Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNFRSF11B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4982
Official gene symbolTNFRSF11B
Full nametumor necrosis factor receptor superfamily, member 11b
Aliases,MGC29565,OCIF,OPG,TR1,
Gene summaryThe protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq]
LocationChromosome: 8   Locus: 8q24
Gene position119964383 - 119935796  Map Viewer
Gene orientationminus
Gene size28588 bp
Gene sequence
OMIM ID602643