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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SLC22A18 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5002
Official gene symbolSLC22A18
Full namesolute carrier family 22, member 18
Aliases,BWR1A,BWSCR1A,DKFZp667A184,HET,IMPT1,ITM,ORCTL2,SLC22A1L,TSSC5,p45-BWR1A,
Gene summaryThis gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p15.5
Gene position2920951 - 2946476  Map Viewer
Gene orientationplus
Gene size25526 bp
Gene sequence
OMIM ID602631