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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for P4HB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5034 Official gene symbol P4HB Full name prolyl 4-hydroxylase, beta polypeptide Aliases ,DSI,ERBA2L,GIT,P4Hbeta,PDI,PDIA1,PHDB,PO4DB,PO4HB,PROHB, Gene summary This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq] Location Chromosome: 17   Locus: 17q25 Gene position 79818544 - 79801034  Map Viewer Gene orientation minus Gene size 17511 bp Gene sequence >P4HB:complement(41985..59495):Length=17511 GAGCCTCGAAGTCCGCCGGCCAATCGAAGGCGGGCCCCAGCGGCGCGTGCGCGCCGCGGC CAGCGCGCGCGGGCGGGGGGGCAGGCGCGCCCCGGACCCAGGATTTATAAAGGCGAGGCC GGGACCGGCGCGCGCTCTCGTCGCCCCCGCTGTCCCGGCGGCGCCAACCGAAGCGCCCCG CCTGATCCGTGTCCGACATGCTGCGCCGCGCTCTGCTGTGCCTGGCCGTGGCCGCCCTGG TGCGCGCCGACGCCCCCGAGGAGGAGGACCACGTCCTGGTGCTGCGGAAAAGCAACTTCG CGGAGGCGCTGGCGGCCCACAAGTACCTGCTGGTGGAGTTCTGTGAGCGCCGGGCCTGGC GGGCGGGCGGGGCTCGGGGCCGCTGAGCCAGGCTCTTGGGACGCAGGCACGGCCCGGCAG CCCCCGGGGTCGGGACCCCCGGCGCGCCCGGAACTGAAGGGCTCCCTTGCTGCCCGCCTT GGGGGCCATGTCAGGGGCTCCCTGGGGGTGAGAGCCGGGCTGGGAGCCGGGGGGCCGTCC CGATGCCCGCCCTGCGCACGGCAGGATCTTCCTGTTAGTGCGAGAAGAACAGGATCGACC TGTGTGAGCAAACAGAGCAAGCCAGTGTCCAGCCTTGCCGAGTCCTCCCCGGGGGCCGAC CCGGAAGGCGCCCCGCTCCTGCCCACCCCACCTTCAGCTTGCCACAGCAGTCCTTCCGAT GGTGTCTCAGAGGAGAATCCCAAGCCTTCCTCACGTCCATAAGGATTTGAGCTCTGTCCC TGGGGTGGGAACCTTGTGCCTGACACAGCTGCTAACTCTATTGACAGATCGTCTTATTCT CACCCTAAGCAACTCAGGGTCTGTGTGCACGGATGTGCATCTCATACTCACAGCTAGTGC TGGTACAGGCCGCCACGGTCACTTCTTCACTTTTGTCTGTAGTCTTAAAGGGAAAGTCTA GGGGAGATCCTTGCCTTAGTTGCCTGTGGGGAATAAGAAGTCAGCAACCATTGAAAGGTT TGTCTGGCTGTGCTGATGGTGACATAGCAGAGTGGGGGCTGGTGTTGGTTGGTGGTAGTT TGTCGTTCACGGCCTCTGTCCTGATATTGCCCAAGAACACCAGGCTATCAGCTCAGCCTT GTGCGTTAGGAGGGGTTATCTTGGTGAGTAGATAAGGTTTTTATGAAGGGAAATGCCAGA GGAAAAAGGGAAGCACTGCTGAGGGATCAAGGCTGCTTTAGGGATCAAGGCTGCTTTCTA GCATCTCATTTCCGCTTCCAGATGCCCCTTGGTGTGGCCACTGCAAGGCTCTGGCCCCTG AGTATGCCAAAGCCGCTGGGAAGCTGAAGGCAGAAGGTTCCGAGATCAGGTTGGCCAAGG TGGACGCCACGGAGGAGTCTGACCTGGCCCAGCAGTACGGCGTGCGCGGCTATCCCACCA TCAAGTTCTTCAGGAATGGAGACACGGCTTCCCCCAAGGAATATACAGGTGTGGCTGTGG CACTGCCCTTGAACTGTCTTTAGAGAGGGACTGGCCTGCCGACTTGGAAGGGCAGGGGCA GCTGTCTGAGCGGTGGGGAGGCCGGGTTCCAGAGGCTTGGAGGGATCCCGTTCCTCAGGC CGGGTTCTCTGTCCACTTGTGCCCTGAGGGTCTTGTGAGGAGTTTTCATCCTGGAAGAAC CTTCGAATGGAGAACCTGTCTTGTCTGGTGCCATCCTGGGGGCGGCTGGCTGAGGTCTGT TTGGAGACTGACCAGCGAGGAGAGGGAGACTGGTGCCTTTCTGGCCACATGGGCTGTTTG TGCTGCCCCCTGTTCCTAGGAGCAGCAGCATGGCTGTAGCTCTCGGGGTGACACCTGCTA GCTGTCGTGTGTAGCGTGCCAGCTGCCGCGTCACGTGCTTGCGTGATTTCTCCTCGCATC CTCTCTGTGAGGCGGGCTTTTCCCAGACAAAGGGCTGAGGCTTAGAGCAGCTGAGTAACA GCATCGAGCCTGTCGGTAGCAGACCTCGAATCCAAGCCCGCCCTGCTCCGTCTGTAGCAC GGGCCCTCAGCTGCTCGTCTGCCGCCTCTGAAGCTGCCGTAGTGGAGGCCGAGCCCCTGT GTAGCCAGATCAGTGACGGTGGCAAAAGAAAACTCGTCTATAAAACCGGTTCTGTGGCAT GTCAGATGCTCATGGTGGGTAGCCCGAAAGCAGCTCATTCCAGTGTTAGCAGGGTTCTCC CCTTAAGCAGGTGTGCCCTGTCCTGTTCTAGTGGCAGCAACTCCGTGGTTGCCTCTCACT TGGCTGTTTTGATGTTTCCTTTTGTCCCCTTAAGCAGGTGTGCCCTGTCCTGTTCTAGTG GCAGCAGCTCTGTGGTTGCCTCTCACTTGGCTGTTTTGATGTTTCCTTTTTTTTTTTTTT TTTTTTTTTTTGAGACAGTCTCGCTCTGTCGTGCAGTGGTGCGATCTCTGCTCACTGCAA CCTCTGCCTCCCGGGTACAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGGGGCTAC AGGTGTGCACCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCA TGTTGGCCAGGATGGTCTCGATCGTGACCTCGTGATCCACCCGTCTCGGCCTCCTAGAGT GCTAGGATTACAGGCGTGATTGATGTTCTCATTTTTTACTCATGTTCACTTTTGGAACGG GAAGTGCTCTGTCCAAAGTCACCGTGGTTCTGTCACTAACACTCAGGTTTGCAGATGAGA TGAGCACTCCTAAATCCACTTGTCACTGGTGACCGTCTTGTTAGCACTGGTGGAATCCTT CTACATCTGAATGGGGTTTTCCCGATTCGGACCAGGGAGTCAAGTTCTAGGAGGGAAAAA GGAGAGGCATCATTCCTTAGCCTCAGTCTCCCAGGAGGAGGAAGTTTCTTTCCTGTCAGT TGACCGCCTTTGGTGGCATAAAAGTGTGTCATCTTCTTCCTGGTCTGGGAGGCATGGAGG GTGGGCCATTGGCGAGAACTCCCGAAACGCCTGGGATAAGTTAGGAGGCGCGGGAGTCAG GTGGGCGGGGCGTCAGCCTGTTCCCAGAGGTAGAAAACTGGCACTGAGTTTTGAGTTACT GTCCACCTCTCTAAAATGAGGCCTGCTGTCAGACTCCTGGGTGAGAACATGTGTTTGATG GATGTACATGTCAAAGAAAATTTAGATAACGCAGAGGACAGGCTGGGTGCGGTGGCTCAT GCCTGTAATCCCAGCACTTTGGGAGGCTGAGACGGGTGGATCACCTGAGGTCAGGAGTTC GAGGCCAGCATGGCCAATATGGTGAAACCCCCGTCTCTACTAAAAATACAAAAATTAGCC GGGCGTGGTGGTGCACGTCTGTAATCCCAGCTACTTGGGAGGCTGACACAGGAGAATCCC TTGAACCTGGGAGGTAAGGTTGCAGTGAGCTGAGATCGTGCCACCGCACTCCAGCCTGGG TGACAGAGTGAGACTTCGTTTCAAAAAATAAAATTTTTAAAATGCAGAGGGCCATCCTGG GCAACATGGTGAAACCCTGTCTACAAAAAATACAAAAATTAGCTAGGGCTGGGCACAGTG GTTCATCCCGGTAATCCCAGCACTTTGGAAGGCCGAGGTGGGCGGACTGCTTAATCCCAG GAGTTTGAGACCATCCTAGGCAACGTGGCAAAACCCCATCTCTACAAAAAATAGAAAAAT TGGCCGGGCATGGTGGCTCACGCATGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGG ATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACACAGTGAAACCCCGTCTCTACTA AAAATACAAAAATTAGCTGGGCATGGTGGCGGGCGCCTGTAATACCAGCTATTTGGGAGG CCGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAGGATGGCGC CACTGCATTCTCCAGCCTGGACGACAGAGGTAGATTCCGTCTCAAAAAAAAAAAAAAAAA AGAAGAAACATTGCTGGGCGCAGTGGCTCACCTCTGTAATCCTAGCACTTTGGGAGACCG CTGAGGCAGGTGTATCACCTGAGGTCAGGAGTGAGACCAGCCTGGCCAACATGGGGAACC CTGTCTCTGCTAAACATACAAAAATTAGCCGGGTGTGGTGGCGGGCACCTATAATCCTAG CTACGCGGGAGGGTCAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAG CCGAGATCACACTATTGCACTCCAGCCTGAGCAACAAGAGCAAAACTCCGCCTCAAAAAA AAAAAAAAAAAAAAGTTAGTTGGGTGTGGTGGCACATGCCTGTGGTCCCAGCTACTTGGG AGCCTGAGGTAGGAGGATTGCTTGAGCCCAGAAGTTCGAGGTTGCAGTGAGCCATGATCA TGCCACTGCACTCTAACCTGGGTGACAGAGCAAGACCCTGTCTTCCAAGAAAAAAAAAAG GGCTGGGATTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGTCGTGGTGGGCAAA CTGCTTGAGCACAGGAGTTAAAGACCAGCCTGGGCAACGTGGCAAAACCCCGTCTCTACA ATAAATACAAAAATGAGCTGGGTGTGGTAGCGTGCATCTGTACCCCAGATACTCAGGAGG CTGAGGTTGGGAAGATTGCTTGAGCCCAGTGGGTGGAGGCTGCAGTGAGCCAAGATTCTG CCACTACCCTCCAGCTGGGTAACAGAGTGAGCCCCTGTGTCAAAAGAAAAAAGAAAATGC AGAGAGATCAGAGAAAAAAAATGGGTTTGTGATCCTGTTATTCAGAGACAGAATCACCCT CTTCCCTCTCCACTCCCCATAAACACAACCACAGTCTCACGTACACTGGGGTTTAGGAGG CGGGCGGACGGCACCGGGCCTCTTCCATGGTGGGAGAACATCTTACTTAGGTTGATTCAG GTGTCCTCAGCCTGGCTGGCAGAGAGCAGAGACGGGAGCAGGCGCGGCAGGGCAGGCGGC ACTCCCTGTTTGAGAGTAGAACCTACATTTGTTTGGGGTTAGCTGGCAGAGAGGCTGATG ACATCGTGAACTGGCTGAAGAAGCGCACGGGCCCGGCTGCCACCACCCTGCCTGACGGCG CAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCTGTCATCGGCTTCTTCAAGGTAG AGACCAGAGCATTCCAGTCTTCCTTCCTTCCGTCATCCATTGAGGAGGGGTCCACAGCCT GCAGCTGGCAGTTCTGCACGTGTCCCCCCTGGCCTGGGCTCTACAGGGTCTGCCCTACTG CTTGGTGCTGCGGGATCATGACGACCTCTGCTTCTCCCTCCTCATTCAGGACGTGGAGTC GGACTCTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGATGACATACCATTTGGGAT CACTTCCAACAGTGACGTGTTCTCCAAATACCAGCTCGACAAAGATGGGGTTGTCCTCTT TAAGAAGGTGAGTGGCCCCAGGCAGCTCTGCCCAGGTTAGTTCTGGGGTTGGTCTGCAGA GGGTGGCGTTGCTCTCCTTATCGTTAAGGGAACCTTGCTCCTGGCACCTTTGGCCCAATA GGTATGTTCTGCAGCTTTGCCAAGTTGGGGTGTTGCGCTGATGCCTGTGGCCTGGTCTTC GCATTCAGCTGTGGGCTTTCTGGCCACTCTCCTGCCACAGCCGCCTCAGAACTGCTTTTG ACTGTTAGCTTTTTTTTTTTTTTCAATTATGATAAAACATGTAACAACATTTGCCCTTTT TTTTTTTTTGGGAGAGTCTTGCTCTGTCACCCATGCTGGAGTGCAGTTGCGTGATCTCGG CTCACTGCACCCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCGGCCTCCCGAGTAG CTGGGACTACAGGCATGCACTACCATGCCCAGCTAATCTTTGTTTTAGTAGAGATGAGAT TTCACCATTTTGGCCAGGATGGTATCAATCTCTTGACCTCGTGATCCACCCACCTCAGCC TCCCAAAGTGCTGGGATTACAGATGTGAGCCACCGCGCCTGGCCCCGTTTGCCTTTTTTT TTTTTGAGATAGGGTTTCTCACTCTGCCGCCCAGGCTGGAGTGCGGTGGTGCATTCTTAG CTCACTGCAACTTCTGCTTCCCAGGCTCAAGTGATCCTCTAACCTCAGCCTCCCGAGCAG CTGGAACTACAGGCGCGTGCCACCACGCTGGGCTGAGTTTTTGTATTTTTTGGTAGACAT GGGGTTTTGCTGTGTTGTCCAGGCTGGTCTTGAACTCCTGAGCTCCGAGTGGTCTGCCTG CCTCAGCCTCCCAAAATGGTGGGATCACAGGCGTGAGCCACCGCGCCCGGCCACGTTTTA ACTATTCTAAAGTATTAACTACATTCAGAGCGTCCTGCAGCATCCCTATTTCCAGAACGT TTTCCTTACCCAGAGGTCTGGAGTATTGGCGCTCTGGGCGTGTTCCCACCCAGGTGGCAC CCACACTTCGTATGCCCCTCAGCCCCAAGGGCATTATGACCCCTAAGGATCCACTGTGAA AACTGCCATCCTGATCCCGCTGTCCTTCTCCTGGGGAAGGGCTCCTGGACAGTGTGGCCT CTTAGCCGCCTCTCCCCGTTACCAGGACACAGCAGGGTCCTTGTTTGCACAGTGTCAAGA TGGGGCCTGTGGGTTTCTATTGTCTCTTTTCTCGGTCACCAGGCAGGTGGGGCTGGGGCC GCACACTTGTGCTCTAGGGACAGCTGAACCTGGATGTGGGTGATGGTGGGTTTGTGCCGC TCAGAGCCAGGGTAGTGTGGATAGGAGAGAAAGTCTCGGGAGAGGAGGGACCTGGGGAGT GAGGGGCAGGAGGGCGGCCGGGGGCGATCGGACCTTCAGCTCCTGTCCTGTGTCGTTTCC AGAGGGGAGAAGAACCTTTTAGACAGCAGCATCATAAGCCAAACGGTCAGACGGGCAGCC TCTGGGATTGGGGCTGAGTGGTTTTGGACACAAGGAACCCATTCACTTTCTTTTTTTTTT TCTTTTTCTTTTTTTGAGACAGAGTCTGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGC GATCTCAGCTCACTGCAAGCTCCGCCTCACGGGTTCACGCCATTCTCCTGCCTCAGCCTC CCGAGTAGCTGGGACTACAGGGCACCCGCCACCACACCCAGCTAATTTTTTTGTATTTTT AGTAGAGACGGGGTTTCACCGTGTTAGCCAGGGTGGTCTCGAACTCCTGACTTCATGATC CGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGACCCATTCACT TTCTGTAGTAAGCACGGAGCATCCAGCACTCCCCGGGACCAGGTAGGAGGGAGGGTAGAG CCAGCTTCCTGGAGCGCGGTGGTGCGGGTGGGTCAGGATGGCTTGCTTCCATGTTCTTGT TCTTGTCATTTAGCTGTTTTTGCAGCCACTTCCTCAAGATAACTCAAGACAGTAGATGCT CTTTACCAGGAGACATTCTCTTGATGTCCCCTGAAGGGAAGAGAGTTGCTAAATTAGTCT ATTGCCATTGCAAGGTGCCCAGGAAATTAAACCTCTGACTAGAAAAAGCCAGTGAAGTGT TGGATAAAGTTGAAGGAACCAAAGGTCTTTTTAGAGCTTTTATTAAAGAGAAAGTTCCAA GTCTTGTCCTGAAACTTGGGTTCTGGGGCAGACTTTCTCCAGAGCCCACGAAACTCGCGA ACCCTGTGTTGTCACACAGCCCACAGCTCCTTCAGTGCCCTGGATGTCTGCAGTGGCCGC TGTGACTCTATGGACAGTTTGGTGATATGTGTCCGCGAAGGCTGGGAGGGTGGTTTCGTT GCTCTTGCCTGCAAAGGCTCACACGTGGCCATCCATGTGGGCTCCCCACAGGTTAACGTT CTGTCTCCATTCTCTGGAGTCCACTAGAGCTGGGCACAGACAAACCCACTTGGGTTTGAT GCCAGTTGGTGGGTGGCGCTTTCCTGCCCACTGAAGGTGGCTCAGGTGTCTGTGATGGCG AACGTGGTCGTTGCAGGCAGCTCCGGGCAGAAGCCCGGCCCCCTGTCCGGTGCACGTGGT AGGGGCTGCCCTGGAAGTCAGAGCTCACCCCGCAGCTGAGAGGATGAGTCCAACTTGTTC CTTTTCCACCAGGCTGTTAACCCCCATCCCTCAAAGTGAGTGAGGCCTTCCTGTGTGTGC AGTGGCCACAGTGGGCAGCCTGGCTGAGTCGGGTGCTCTTGTGTGGCCCGCTCTTGCCTG CTCTTCCCTTCCTTCCCTAGCAGGCACTGCAACCCAGGAAAACCTCTGCGGGGGCTGCTG GTCACTGGCACCATGGGTGTGAGAGCTTCTGATATTTCACTTTTTCTTCTCCCCCAGCTG GCAGCACTGGGCCTGTTATTGTTGTTTGAGAAAGGGTCTCGCTCTGTTACCAGGCTGGAG TGCGGTGGCACAATCACACTTCACTGCAGCTTCGACCTCCTGGGCTCAAGCAGTCCTCCC ACCCCAGCCTGCTGAGTAGCTGGGACCACAGGTGTGCACCACCGCACCTGGCTATTTTTT AATACTTCTGTGGAAATGGGGTTTCACCGTGTTGCCCAGGCTGGTCTCGAACTTCTGAGC TCAAGCAATCCTCCTGCCTCAGCCTGCCAAAACATTGGGGTTACAGGCGTGAGCCATACC ACCCGGCCTGCATTGGGCGTTTCTATGCTGTTTGTCACCGTGGCCTGGCAGGGCTGGCCT CCTGCTGCTGTGCCCTGCTAAGTGGACCAGTTTCCCTTACCGCAGTAGACCGTGATTGAG TGTGGTGTAGCATCTCTGCTGAAACGATGGCAGCCCTGGGACAGCTGCGGCAGTGTCTCC TCCTGGCTTCTTGGCATGAGATGGTGTAGGCGGCGCCTGACACTCTGGAGGGAGTCAGAG ACATTGTTCTGCAGGGGTGGGGGGATTTCGTTTGCCTGCAGTTGCGGCCCGGCGTTACTC CTGGGCACAGTGCGAGCCCACCCGTGCCACTGGGAGCACGGCTGTGATCAGCAGCTCATG TTCCAAAGGATTCCCTCCAAGGGCCTCCTGAACTTGGCTTTTCTGCCTCTCCTTACCCGC CTTTGCCCCTCTGGGGAAGAGGTAGCAGGCTTAGAAGCCTCTGCCCCTCGGGTTCGGGCA GGGTGGTTGGTGCTTGTGCCCTGGTTTAACATCAGCTCCTTGGCAGTCAGGCCAGGCCAG GGTGGCCCAGGCACAGCGTGCACAAGAGCAGGGAGTGGCACCTGGTCTCTAAGTTACTCT GCAGACGCATACATGGAAACGGCCAGTAAGAAAGGATGCGTGATTTATTTCCCCAAGTCT CATTTAAGAAGTTTGAGGAGGCCGGGTGCAGGGGCTCATGCCTGTAATCCCAGCACTTTG GGAGGCTGAGGTGGGCGGGTCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGT GAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCGGGCACCTGTA GTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACTCAGGAGGCGGAGCTTG CAGTGAGCCGAGAAGCACCACTGCACTCCAGCGTAGGCGACAGAGCAAGACTCTGTCTCA AAAAAAAAAAAGGTTCAAGGGGACCAGGCTTGGTGGCTCACACCTGTGATCCCAGCACTT AGGGAGGCCAGGACAAGAGGATTGCTTGAGGCCAGGAGTCTGAGACCAGCCTGGGCAACA TAGTAAGACTGTCTCTACAAAAAGTAAAAATAAAATAAATTTTTTTGGCTGGACACGCTG GCTCACGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACCTGAAGTCAG GAGCTTGAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTAATAAAAATACAAAATT TGCCAGGCGTGTTGGCACATGCCTATAATCCCAGCTACTTGCGAGGCTGAGGCAGGAGAA TTACTTGAACCCAAGAGGCGGAGATTGCAATGAGGCAAGATCGAGATCGTGCCATTGCAC TCTAGCCAGGGAAACAAGAGCAAAACTCAGTCTCAAAATAGATAAAATAAAATAAAATAA ATTAAATAAATAAGTATTTTAAAAAGTAGTTCTGTCCAGGTGCAGTGGCTCACACCTGTA ATTCCAGCACTTTGGGAGGCCGAAGCAGGCCGATCACCTGAGGTCGGGAGTTCAAGACCA GCCTGACCAACATGGAGAAAGAAACTCCATCTCTACTAAAAAAACAAAATTAGCCAGGCG TGGTGGCGCGTACCTGTAATCCCAGCTACTTGGGAGGCAGAGGCAGGAGAATTGCTTTAA CCCGGGAGGCAGAGGTTGCAGTGAGCCAAGATCCTGCCACTGCACTCTAGCCTGGGCAAC AAGAGTGAAACTCCGTCTCAAAAAAAAAATAAAATAGTTTGGGCCGGGCTCAGTGGCTCA CACTTATAATCCCAGCACTTTAGGAGGCCGAGGCAAGTGGATCACCTGGGGTCAGGAGTT CAAGACCAGCCTGGCCAACATGGTAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCC AGGCGTGGTGGCGGGTGCCTGTGATCCCAGCTACTCGGGAGGCTGAGGAAAGAGAATTGC TGGAACTCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCTGG GTGACAATAGCAAAACTCCGTCTCAAAAAATAAAAAAATAAATAAATTTTAAAAATAAAT AAAAAAGTAGTTCGGGGGAATGATGGAAGGCTCACCCAAAATTCTCACTTGAAGAGCCTC AGCACAGGGGCGCCTCTCTGAGCCTGAGCCGAGGCCGCATCCTCAGCTGCAGGCTGACCC CTCGTGGTTGGGGCGCCACAGCCTCTCCATCTTGTGGCCTTAGGACTCCCTGAAGCTGCC GTGCATTATTAGGGGTCCCCAGGGCCTTACAGGCACGTGGATTGCGCCTTTCAGGATCTG TTGTATTAGAAACTAGAACTAAGAATGTAAAAAATCGTTTTTTTCTCTCTATTTATTTTT ATTTTTTATTTTTTGAGATGAAGTCTTGCTCTGTTGCCAGGCTCGAATGCAGTGGCACGA TCTGGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCC AAGTAGTTGGGATTACAGGCACCCGCCACCACGCCCAGCTAATTTTTGTATTTCTAGTAA AGACGACGTTTTACCATGTTGGATTAGGCTGCTCTGAAACTCCTGGCTTCAGGTGATCCG CCCGCCTCAGCCTCCCAAAGTACTAGGATTACAGGCGTGAGCCACCACGCCTGGCCTGTT TCACTCGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCACTGCAATGTCTACCTCCCAG ACTCAAGCAATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCAGGTGCCACC ATACCCAACTGATTTTTGTATTTTTGTATTTTTTTTTTTTTTTGAGACAGAGTCTTGCTC TGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCTGCCTCCCGG GTTCAAGTGTTTCTTCTGCCTCAGTCTCCCGAGCAGCTGGGATTACAGGTGTGCACCACC ACACCCAGCTAAATTTTTGTATTTTTGGTAGAGTCGAGGTTTCACCATGTTGGCCAGGCT GGTCCCAAACTCGTGAACTCAAGTGATCCACCTGCCTCAGCCTCCCAAACTGCTAGGATT ACAGGTGTGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGA GTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACCGCAACCTC CGCCTCCCGGGTCCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGATTACAGGT GCCCGCCACCACGCCCAGCTTATTTTTGTATTTTTAGTAGAGATGGGGTTTTACCGTGTT GGCCAGGCTGGTCTCGAACTCCTGGTCTCAAGCGATCCACCCATCTTGGCCTCCCAAAGT GCTGGGCTTACAGGCCTGAGCCACTGTAGCCAAATTTATTTTAAAAGAATAATAATCCCA TTACATGTTATCATAAATCACATCTTTACGGAAACTAGTTTGTCCCAGACAAAAACAATT TAGTGCTGAGTGATGTTTTAGATTCCTCCAGCAGGATTCTCCTCTCCTGCCCTCCTGCTC TTGCGACACCATGCGCCCAGCAGCCTCTGTGGGTCTGTGCCGCAGCACGTGAGAGGGAGA GTGAAAAGGCAGAGGCCAGAGAAGTGTGAGTGTGAAAATAGCTTTGACCAGCCGGGCGCG GTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACGAGGTAA GGAGATTGAGACCATCCTGGCTAACGTGGTGAAACCCATCTCTACTAAAAATACCAAAAA TTAGCCGGTGGTGGCGGGCGCCTATAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAAT GGCTTGAATCCGGGAGGCGGAGCTTGCAGTGAGTGGAGATCACGCCACTGCACTCCAGCC TGGGAGACACAGCAAGACTCCATCACAAAAAAAAAAAAAAAAAGATCAAGACCTTCGTGG CCAACATGGTAATACCCCATCTCGACTAAAAATACAAAAAAAAATTAGCCAGGCATGGTG GCAGGCGCCTGTAGTCCTAGCTACTCGGGAGGCTAAGGCAGGAAAATCACTTGAACCTGG GAGGCAGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGC GAGACTGTCTCAAAAACAAATAAAAAAGAAAATAGCTTTGACCACATGGGTGCCCTGAAA AGGCTAGGGGCCCTGGGGATGGGCCACACTTCAAGGTTGCTGGAGGACCACGTGCGCCAG GCTTGCATTGTGGATGTGAAGCCAGCTGTTGAATTCACGGGCAGCCATAAGGCCGTGACC AGAGCCAGTCTTACTGTCGAGGAACAGCCATGTCCTGTACCCATTGCTGGACCTGTGGCT CGAAACCCCACGGGAGGGCAGGGCTGCTGGCTGCTGTGACTTCCCACGTCCAGGGAGACC CGGGCCCAGGGGCTGTGCTCCCAGCAGCAATGCTCAGTCAGGGCCCTCTTTCTGTCCACA GTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCTGGACTT TATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGGTGCGGCTGCCCTG CAGCCCCCAGGCTGGGGATGGGGAGGAGTGGGTTGGGGGTGGCATGAGGCTCCCGGTCAC CACTGCTGTCCAGCGTCTGACATTGGAGGCCATTGGGAGAATCTTCTGCATTAATAGTGT GTGACTCAGACCCAGTAACTTAAGTTTATAACACAGACAGCCCCGAAGATTTTTGGAGGT GAAATCAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAA CTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGGTGAGCTGCTCTTCTGGG TGGCTCGTGGGGCGGTGCCAGGGAGCAGTACAACTCTTCCCGAGGTGACAAGTGTGGGGC CTTCCTGAGGCTGCCTGCTGGACTGGATCGGGCACCTGATTCAGGACAGCCTGGATGTAG GCGAGGGGCCAGCCAGGCCAGACCTCTGCTCCCAGTCACCTGCTGGTCTGGTTGGGCAAC CCCGGAATCCAGGTTGGAGGAAAAAGGCACCGGAGCACGGTCTGCTTCCGAGCAAAGTCA GGGCTGGAGGCAGAGGCCAGCCGTCTCCCGCACCTGTGCAACCTCCTTTTCTCCCCCAGA TCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTG GCCTGAAGAAGGAAGAGTGCCCGGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCA AGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCT TCCTGGAGGGCAAAATCAAGGTGCAGGCGCGTCCCCGGGCCAGGGCTGCCTCCCGGGTAG AGCCGCCACCTTGGGGTCTCTGGGCTCTCAGTGTCCTGGGCTTCGTCCTCAAAGTAAGAT CTTCAGAGTAAGAGGACGGAGCCCAAGATGGTGTGAAGACCACCATTCTTGTCACACCTT TGGGGACCTGTAGGAGCCCTCTTGTCCACACGGCTGGCCCAGATGCTCCTCAGGGAAACC TCCTGGCCGGCGAGGGTGCGGCCTGCGTGGGCTCATTGGGCCCAGCCCACTGGCCCAGCC TTCTCTTTCTGGATTCTTGGCACTGTTGGTGTCTGCGGCTGCCACCCTGGTGTGCCCAGG GCAGCCACGCACCTCAGTCCCGGGCAGGGTGAGGGTTGGGGAGCTCTGTGGTCCCCCAGG CATCGCCGCCCCTCACCGTGCCCTGCCTGCCCTCCAGCCCCACCTGATGAGCCAGGAGCT GCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAACTTTGAAGACGT GGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTGTAAGTGTTGCCCTTTCAGCTC CCCAGGTCCGTGCCACCAGGGCACGCGCAAGGTAGGCAGACTCCTGGGGAAGCGTCTGCC AGTGGCTTTGTGTCCAGGACACACCCTAGAACTGCTTTCTTTTCAGATGCCCCATGGTGT GGTCACTGCAAACAGTTGGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCAT GAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAAAGTG CACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTGCGCCTTCCC TCCAGACGGGGCTGGGGCGGGCTCTGGGAAGAGCAGTGGTCCCCACGCCAGCCTGGGTGC CTCTCTGGAAGGAGCCTGGGGCTAGTCAGGTGGGAGAAGAGCTGTGGGAGCTCCTTCAGA AGCACCCACCTTTGTTTTTCGAGAGAGATGGGATCTCACTATATTGCCTAGGCTGTTTTT GAACTCCCAATGTGCTGGATTCCGGGTGTGAGCCACCGGACCGGGCCTGCTCTGCCTTTC TCTAGGGAGGAGGAGCCAATGCCAGGAGATTGGCTCTGGGCCGGGACCAGCCCCTGCACT CATCCCTGTCTTCCACAGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTTTAAG AAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGTGAGTGGGGTCACA GCCCTGGGCTGGTCTCTGGGATTCAGCCCCTTGGCCCCACGGGACATGCCCACTTGGGCT CGGCTTGTGATGGGAATGGTGCCATTGGAGGCACGTCTGTGCGTCCAGGGCTCTGGGGCC CCACACCTTCGCCCAGCAGGGCAAGGGATGTGCTCCCAGTGCTCTGCTGAAACAGCTCTC CCTGGCCAGCACTTCTTTAGGGGACGACGTTGAAGGCATCTTTAAAAACCAGATTTTGCT TAGAAAACCTTTTCAGACACATGGCACCGGTTCCTCACATGCTGCTAACTTGGACTCAGA GGTCCATCCCCAGCCCGCTGGCGGGGCCCGGGCACAAGGGCGCAGACATGGGTCTGCCCT CGGGAGTTTAGTCCTGCCCGTCAGCGCGTGGCCAGCAGCAGTGGTGACTCTGCCGGGGAA GCAGGAAGGCTGGTGTTGGGAGGATGCGGCAGGGGCGGGGTGCTTGACCATGGTGAAGGA GATGAGGGCATGGTCAGCCCAGGCTGGCAGGGCCTGCTGGGAGTGCTGGTGCACAGTGGG AGGTGGGAATACTCTGCCCAGGCTGGGGATGGAGGGCCGGCCCCTGGTGCTGCCTGTGGC CTGTCATTGGCCAGAGCCCAAGGGTTGGAAGTAGAATGGTCACACCCCAGTGGTGACTGT GCCTGGACTTCATGCTGGGGCTGTTGTCCCTGCCGAGATGTGGACCCTCTGTAGACTCCA TGGTGCCAAGCTGGGAGACACACATACGCCTTCCATGCCCAGTGGAAGGGTCCAAGGCTG AGCTGGGATTCCCAGGGTTCCTGACACAGTGGGGGCTCTGATTCATCCTGCTATAGGCAG AAATCCCCCAGGCGTCACTCTTCCTGGGAAGACCCCTGTGTAGCTCGTAAAGACCAGGGT TGGCTGCTCCAGTGGCCGGTGGCCATGTCCGCCGTGGCCGGCTAGTCCCCGGTGTGAGCA GTGTGGGGTGCTGGGGGCCGGCAGCCTCAGCTGTTGCAGCCAACCTGCCCGCCCCGCCCC TTTTCCTGTATCCCAGGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGAGGA AGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGC TGCCGAGACCCCTCGGGGGCTGCACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGC CTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGACACCTCACC CCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGA TCCATCTCCAGGCAGCCCACCCTGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTT CATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCCTCCCTCCC GCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGAC ATCAGGGTATTTGTTCCACCTTGGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGG AGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCCATGACTGA TCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCA TGCCTGGAAGAGGAGCTGGTGGCTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCC CCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACTGGCCTCTC TACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGA GGTGGCCAAGGATGCTGGAGCTGAATCAGACGCTGACAGTTCTTCAGGCATTTCTATTTC ACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACCTGT OMIM ID 176790