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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL21R (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID50615
Official gene symbolIL21R
Full nameinterleukin 21 receptor
Aliases,MGC10967,NILR,
Gene summaryThe protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p11
Gene position27413483 - 27463363  Map Viewer
Gene orientationplus
Gene size49881 bp
Gene sequence
OMIM ID605383