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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PAK3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5063
Official gene symbolPAK3
Full namep21 protein (Cdc42/Rac)-activated kinase 3
Aliases,CDKN1A,MRX30,MRX47,OPHN3,PAK3beta,bPAK,hPAK3,
Gene summaryPAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
LocationChromosome: X   Locus: Xq23
Gene position110187513 - 110464173  Map Viewer
Gene orientationplus
Gene size276661 bp
Gene sequence
OMIM ID300142