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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RDH8 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 50700 Official gene symbol RDH8 Full name retinol dehydrogenase 8 (all-trans) Aliases ,PRRDH,SDR28C2, Gene summary All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).[supplied by OMIM] Location Chromosome: 19   Locus: 19p13.2-p13.3 Gene position 10123925 - 10132954  Map Viewer Gene orientation plus Gene size 9030 bp Gene sequence >RDH8:1386727..1395756:Length=9030 TGTCTATAGTAGGTGCGGAGAAGAAATGTTTGGCAGATGAAGAAAATGAGGTGCAGAGAG GATTTAAGAGATTCTCTCTTACTGCCTGTTCAGGGTCAGTCCAGAATTGAGGGTCTCCGG GGGAGGGCAGAGGCTTTGCCCTGCAGGGGATCTGTGGGAGGGGGTTAGGAGGGAGCAGAT GAGCCCAGGATGAATGGTCAGAGTCAGGTGCTGCCCGGCGGAGGTCACGAGTCCAGGGAG GGGATCAACATGGCCGCTGCACCCCGGACTGTGTTGATCTCCGGCTGCTCATCAGGAATT GGTCTGGAACTTGCAGTGCAACTGGCCCATGACCCCAAGAAGCGCTACCAGGGTAAGAAG TGCAGGGTGGCACTAGGAGGCAGCCGGGTGGAAACGGCTTCCCCAGCACTGTCTCCCCTA CCCATCCCTCCCAGCTGCACTTGTGGGCTTGGGGAGACCCAGGATTCCCTCCAGGAATCA TCCCCTCATCCTAGAAATATTTCTTGAGCATCTTCTGGGTGCTCTGAATGCTGGCAACAC AACTGGAGATGAAATAGACAAAAATCTCAGCCCTCAGGACGGGTGTCATGTGGGGAGGAG AGGGAGAATGGGTGATAAACAGATAAAAAGAAATTGTTGCTCTATCTGGTGGGAATAAGT GCTGAGACACAAAATAAAGCATGCTGAGAGTGGCAGGGGGTGGGTGGGGGTTATTTTTAG AAGGGTTTCACTAGGGCATTTCCTAGATTGGAATAATCACTACCCTGATGCTCACTCTTC CACGTCTCCCCAGATTATTGCTTTTACTGAGATAAGCTTCTTAAGTGCTCCTGACCTTGG GGGTTGAAGGGATGGCCTTCTAGTTCTAAGAACTTGCCCTTCTGCACCTCTAGAATAAAT CCCTGGGACCTGCATCCTAACCAACCAGGAGAACCCCTGACCCAGAGGGAGCATGCTGGA GTCAAAGTGGGCAAAGGGTTGTTACTTACAAAGAGGCGACTGGGGGTGAGGGCATTGCCC CAGTTGGCAGGGCTGCTTCTCCCAGCCCTCTGCCCTCTGTTTTAGAGACGCACACAGCTT TGAGCATGACAGCCTGAATGCCAGTGTGCAGGGAATAACGTGTGTCCCTATGGGCGGGCA GATGGGTGTATGAAACTGCTGGAGGCTAATGTTTATGGAGCTTTTACAATGCACCAAGCT GCATTCTAAGTGCCCTGAATCCAGGAAGTCATTTAATCCTCACATCACACCCGTGAGGCA GGCACAATCATTCACCCCATTTTATTATTATTTTATTATTTATTTATTTTGAGTCAGAGT CTTGCTCTGTCACCCAGGCTGAGTGCAGTGGTGCATCTTGGCTCACTGCAGCCTCCACTT CCCACGTTCAAGTGATTTTCATGCCTTGACCTCCCGAGTTTCTGGGATTAAGGCATGCAC CACCACACCCGGCTAAGTTTTTGTATTTTTAATAGACAAGGTTTCACCATGTTGGCCAGA CCGGTCTCGAACTCCTGGTCTCAGGTGATCTGCCTGCCTGGGCCTCCCAAAGTGCTGGGA TTACAGGCATGAGCCACCGTGCCTGGCCTGCCCTATTTTAGAAATGAGGAAACTAAGGTG CAGACTGTGAAAGGTCTTTGCTCAAGGTCTCCCAGCTGCAAAGTAGCAGAGCTGGGATTT GAACTCAGGCAGCCCATCCCTTGCACCCATGTTTCCCACTATATCACATGTAGATGCAAG TGACCCCATTCACGTGCCTGCTACCCACAAATCACACTGACCCGAAGACAAGAGGCAAAT GCCCCCAGGAGTGTTCATGGGTGATTATGGGTGCACACATTGGGGGATATCAAACACGTA TGCTGGTGCATGTGCAGACATAGTACATATGCTGAGGTCCTGCTTAAGAACATAAGCTTG AGGCTGGGCACAGTGGCTCATGCCTGTAATCTCAGCACTTTGGGAGGCCTAGGTGGACAG ATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTAC TAAAAATACAAAAAATTAGCCAGGCGTGGTGGTGGATGCCTGTAGTCCCAGCTATTCGGG AGGCTGAGGCAGAAGAATGGCGTGAACCTGTGGGGTGGAGCTTGCAGTGAGTCGAGATCA TGCCACTGCACTCCAGCCTAAGCGACAGAGCATGACTCTGTCTCAATAAATAAATAAATA AATATACAAAAATTAGCCAGGCATGGTGGCAGTGCCTATAATCCCAGCTACTTGAGAGGC TAAGGCAGGAGAATTGCTTGAACCGGGAGACAGAGGTTGCAGTGAGCTGAGATTTCACCA CTGTATTCCAGCCTGGGCACCAAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAGGGCAT AAAAGCTTGGCCAGGTGCTGTGGCTCTCTGGCTCCTCACGCCTGTAATCCCAGCACTTTG GGAGGATGAGGTGGGCAGATCACCTGAGGTTCGAGACCAGGCTGACCAATATGGTGAAAC CCCGTCTCTACTAAAAATACAAAAGATTAGCCAGGTGTGGTGGCAGGCACCTGTACCCCT GTAATCCCAGCTACTCGGGAGGCTGAGGCAGGGGAATTGCTTGAACCCAGGAGGTGGAGG TTGCAGTGAGCCGAGATTGCACCCCTGTACTCCAGACTGGGCAACAAACAAGAGTGAAAC TTCGTCTCAAAAAAAAAATATATATATATATATGGCTATTCACTTCAGTGTTCATATATG CACATATGTTGGCTATAGTTGTGTATGCATTTTTTTCATGGCAATCTGTTTTATGTTTAT ATATTTTATTGTCTTACCTACTAGGCTATAAATTCCATGAAGGCAGAAACTTTATCTTAT TTATTTATTTATTTATTTATTTATTTATTTATTTATTTTGAGACAGTCTCGCTCTGTTGC CAGGCTGGAGTGCAGTGGCGCTATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACG CCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCTGCCACCACGCCAG GCTAATTTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGG ATGGTCTCGATCTCCTGACCTCGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATT ACAGGCGTGAGCCACCGCGCCAGGCCGCCCGGCCTTATTTTTTATTTTTTGAGACAGGGT CTCACTCTCTCACCCAGACGGTAGTGCAGTGGCTCCATCTCGGCTCACTGCAGCCTCAAC CTCCTGGGCTCAAGCAATCCTCCCACCACAGCCTCCCAAGTAGCCAGGACTACAGGTGGG GGCCACCCACCACACCTGGCAAATTTGTAAAATATAATTTTTTTGTAGAGATGGGATCTC GCTATACTTCCCAGGCTGGTCTCAAACTCCTGGGGTCAAGCAATCCTCCCACCTCAGCTT CCCAACGTGCTGGGATTACAGGCTTGAGCCACCACACCTGGTGACTTTATCTTATTTCAT GCCATAGCCTCAGCACCTAGAATAGGGCATAGTGTATAGTAGATGCTCAATAAATGTCTG TTGAACTCATGGTTGGAAGGATGGATATAGGTACGTGGAGATGCGTGTACACAAGTGTGC ACTTGTTGGCTGAGTGATAAATGTAGGTGTGTAAACTTGTGAGTTTCCATCTCTCTGTGA CTTGTAACGCAAGATCACAGACACGTGGCGCCCACACCAAGGGGAAAGGAGCTCAGTGCC TGTCCCTGCTTTACTCTCTGCCCCGCAGTCGTGGCCACCATGAGGGACCTGGGGAAGAAG GAGACACTGGAGGCAGCTGCTGGGGAGGCTCTGGGGCAGACCCTCACCGTGGCCCAGCTG GACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATCCAGGGAGAAGTGGAC GTGCTGGGTGAGACTTCACAGCCCCTGATTCACTAAGCCCCATCCTGGTCTGAGTATAGA CCCTCAATATGGCAAGGTCTGAGCACCAGCTCTCTGGCTTCTTCAGCAATCTCTGAACCT GGGCAGAAGGGGTAGACCAGTTGGCCAAGAGGGGTAGACCAGTTGGTCCTACCAATTGAT TTATTAAGGGCTGGGTGCAGTGGCTCATACCTGTAATCCTAGCACTTTGGGAGGCCGAGA CAGGAGGATTGACCAGCCTCAGCAAAATAGTGAGACTCTGACTCTACAAAAAAATTAAAA ATTAGCCAGTCATAGTGGTGCATGCCTAATCCCAGCTACTCGGGAGGCCAAGGTGGGAGG ATCCCTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGTTATGACAGAGCCAGTCTGGGGAGA CAGAGTAAGACCTTGTCTCAAAAATAATTTTTTTTTTGAGACGGAGTCTTGCTCTGCGCC CAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAG CAATTCTCCTGCCTCGCCTCCTGAGTAGCTGGGATTACAGGTGCCTGCCACCATGCCCAG CTAATTTTTGTATTTTTCTTAGAGACGAGGTTTCACCGTGTTGGTCAGGCTGGTCTCAAA CTCCTGACCTCAAGTGATCCGCCCACCTCGACCTCCCAGAGTGCTGGAATTACAGGCATG CACCACCACACCTGGCCAAAAATCAATTTTTTTTGAGATGGAATTTCACTCTTGTTGCCT AGGCTAGAGTGCAATGGCGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGT GATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCAGGCGCCACCACACTTGG CTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTCATCAGGCTGGTCTCGAAG CCTGACCTCAGGTGATCCACTCACCTTGGCCTCCCGAAGTGCTGAGATTACAGGCATGAG CCACCATGCCCAGCTCAAAAATCAATTTTTTTAAAAAACAAAAATATTAGAGACACTAGT AACAATCTGAGGCCTGGAGGTGGGGCAGATTTTATGGAATAGAAATTCTCATATATGGAG AAAGCCATATGTGGTTGGGAAAATTACTTGGATGAGTCACTTGGGGAAGACAGCATGATA CAGAAATAAGTCATAAGGTCCCTAACCTTCGCAGGAAGGTGGGTGTCGCTGTCTTGATGT AATTTGGGGTCAGAATTGAATTGCTCATGGATTAAGGGGGGCACTATTCCCAGCAGCCCT TCCTCCCACTCAGGGCTGAGGATCCCCTATGACAAATGCTAAACTGTGTTTAAAGGTTAC CAAGGTTTCATATTTGTCCACCCAAGATACCCTGGACTGGCCTTGGACTTGGAGTACGGG GTGAGGTGCTTCAGGGAGTGTCTAGAAGTAATGCTAGAAGAGTGAGGGACTTTAAGGTAA CCCTTAGTACCTCTTCTCTTAGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAG GGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTTCGGAGCTGTCCGT CTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATC AGCAGTGTCATGGGCCTGCAGGGTGAGCTGTGGGGACCCAACCCTGGAAATCCCACCAGT GTCTGATCCTCCCCAGACTGGGAGGATGGCGAATGGGTTTTAGATCATATTCTAAATTAG CATGGACCCTGGGCACGGTGATTCATGCCTGTAATCTTAGCACTTTGGGAGGCTGAGACG GGTGGATTGCCTGAGCTCAGGAGTTTGAGACCAGCCTGGGCAACATGGTGAAAGCCCGTT CCTACTAAAATACAAAACAATCAGCCAGGCATGGTGGCATGTGCCTGTAATCCCAGCTAC TCAGGAGGCTGAGGCACGAGAATTCCTTGAACCTGGGAGGTGTAGGTTGCAGTGAGCCAA GATCGTGCCACTGCACTCCAGCCTAGGCAACAAAGTGAAACTCTGTCTCAAAAAAAATAA TAATAAAATAAAATAAATTAGCCTGGAGAATTGTGTTCAGAAGGATTCTGAAGTTCAGAA GGAAAAAGTGGCCAGACATGGTGACTCACGTCTATAATCCCAGCACTTTGCGTGGCCTAG GCAGGAGGGCTGTTTGAGCTCAGGAGTTTGAGACCAGCCTGGTCAACACAGGGAGTCCTC ATCACTACTAAAAATTTTTTTAGAATTGGGCCAGGCACGGTGACTCATGCCTGTAATCCC AACACTTTGGGAGGCCGAGGCAGGTGGATTACCCAAGATCAGGAGTTCAAGACCAGCCTG GCCAACATTATGAAATCCCATCTCTACTAAAAATACAAAAAAATTAGCCGTGTGTGGTGG CACACACCTGTAGTCCCAGCTACTCGGGGTGCTGAAGCAGGAGAATTGCTTGAGCCCAGG AGGCAGAGGTTGCAATGAGCTGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAAGAGC AAGACTCTGTCTAAAAAAAATAAATAAATAAGTAAACAAACAAACAAACAAAAAACAACA ACAAAACTTTGGCCAGATGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGA GGCTGATGGATCACTTGAGGTCAGGAGTTGGAGACCAGAATGGCCAACATGGTGAAACTC CGTCTCTAGTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGTGCACCTGTAGTCCCAGC TACTCAGGAGGCTGAGGCAGGAGATTCACTTGATCTCAGGAGGCAGAGGCTGCACTCCAG CCTGAACGACAGAGTGAGACTCCGTCTCCCCCCCGCCAAAAAAAAATTAAATTAAATAAA AAAATCAGCCAAGCATCCTAGTGTGTGCCTGTAGTCCCAGTTACTCAGGAAGCTGAAGTG GGAGGATCGCTTAAGCTCAGGAGTTCAAGGCTGCAGTGAGCCATGATTGCACCACTGCAC CCCAGACTGCAGAACAGAGCAACACCTTATCAAAAAAGAAAAAGAAAAAGAGAGAGAGAG AGAAGGAAGGAAGGAGGGAGGGAGGGAGGGAGGAAGGAAGGAAGGGAGGGAGGAAGAGAG ACAAGGGCCCTAATGAAGAGAAAAATGAAGGGGATCCCCAAGCGGCCCCAAAGGTTTAGA GAATGGAGGGAAATAGGGGAGTTTCCTGGGACCAGGTGGAGCTGGGAGGAGGTGGCACCC GGCACCCGAGAACAACCTCTTTCTGACCCCATATGACCCCATCACACAATGCCATACACC CATCATCTTGGCACCATGTATCTGCTTTCTCTGGTTCCCACATCCTCTTTGCTCTGTCTC CCAAAGACCCCATCACCCTGGAACCCACAAAGCCCACCTCCCAGACCCTCAAAGAGCTCT CCTCCCTCTGACCCTCACAGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTCGC CCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTTCAACATCTTGTGAGG CGGGCACGTGGGCAGAGGGGGCTTGGAGCCAGTGATGGGGAGGTGGCATCGAAAGGGGGA GAGGAGAGATGAAGACAATGAAGCTGAGTGCAGTGGCTCACACCTGTAAGTCCAGCGTTT TGAGAGGCTGAAATGGGAGGATCGCTTGAGGTCAGGCATTTGAGACCAGCCTGGGCAACA TAGCGAGACCCCCATCTCAGCCCAAAATTTAAAAATTAGCCAAGGGTGGTGGTGTGTGTA CCTGCAGTCCCAGCTACTCAGGAGGCTGAGGCGGAGGATTGTTTGAACCCAGGAGTTGGA GGCTGCAGACAGCTATGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCT GTATCTTAAAAAAAAAAAAAAATGGACAAAATAGGTCAGGGAGTGGTTGGGGCATCAGAC TTACACTACCCATGCCTGGTCGCCAGCATCTCCCTGGTGGAGCCAGGCCCCGTGGTCACC GAGTTTGAGGGGAAGCTTCTGGCGCAGGTTTCTATGGCTGAGTTCCCAGGCACTGACCCT GAGACCCTGCACTACTTCCGGGACCTCTATCTCCCAGCCTCCAGGAAGCTGTTTTGCTCC GTGGGACAGAACCCACAGGACGTGGTTCAGGTGAGTGAAGGGCCCAGAGCCCCAAGACGT GGCTCAGGTATGTTGCGGGGTGAGGCCCTCCCTGGGTCCCAGCGCTCAGGGCCTCCATTC TGCAGGCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACA TCCGCTACTCGCCGCTGACCACGCTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGC GAACGACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCTTCAATGTC TGTCCTGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGAGCAGAACAGAGCTTCACGA TCCCCATCCCTGAACAACCAGACCTCTTCATTCCACATCTAATTCAAAGGATGAACAGAC TCTTCATTTATTCATTCTGCAAACTCCCCCTCCCCTCCTCTGTGCCTAGACATGGCTAGA ATCCCAGAAGGGCCTTTATTTTCAGGCATAGACTCCTCTGTGGTCACAGCTGGAGCACAG AGAGGGACCCTGGGAACTTGGCCTGGGAAGCCCAGAGCAGGAAGCCACAGCTGTCTCTGG GAAAGCAAGGGAGGCTTCCTGGAGGAAGCGGCATTGTTATGAGCCTTGAAGGAAGAGACA GACTCTGCTACATTCAACCTCGTGACTTCATGATCCTGGGCCTGAGAACACAGGAATGAT TCATAGCCCACCCCCCACCTCCATGCATACACCAGAGCTCTGTGGACCAAGGGGTCATTC CTGGTCACACACTCCATCAGCAAAATGTATTTGAGCACACACCAGCAATGTATGTATATT TTTTCCATTAAATATATATTTATAACCACA OMIM ID 608575