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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for F11R (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID50848
Official gene symbolF11R
Full nameF11 receptor
Aliases,CD321,JAM,JAM1,JAMA,JCAM,KAT,PAM-1,
Gene summaryTight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q21.2-q21.3
Gene position160991133 - 160965001  Map Viewer
Gene orientationminus
Gene size26133 bp
Gene sequence
OMIM ID605721