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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SEPSECS (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51091
Official gene symbolSEPSECS
Full nameSep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Aliases,DKFZp434B1417,LP,MGC161491,SLA,SLA/LP,
Gene summaryThe 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).[supplied by OMIM]
LocationChromosome: 4   Locus: 4p15.2
Gene position25162204 - 25121627  Map Viewer
Gene orientationminus
Gene size40578 bp
Gene sequence
OMIM ID613009