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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for APH1A (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 51107 Official gene symbol APH1A Full name anterior pharynx defective 1 homolog A (C. elegans) Aliases ,6530402N02Rik,APH-1,APH-1A,CGI-78, Gene summary APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM] Location Chromosome: 1   Locus: 1p36.13-q31.3 Gene position 150241532 - 150237799  Map Viewer Gene orientation minus Gene size 3734 bp Gene sequence >APH1A:complement(1726441..1730174):Length=3734 GGCGACTACAACTCCCAGCAGGTCGAGCAGCTCCGCCCGCGCTGATTCTCCATTGGCCTT CCGGGGGTGGGGATTAGATGGGAGGTGGCCGTGGGGCTGCGGCCGGGATTTGTCCCCTCT TCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCC CCTTCCCCGGGGTCTGGGGGTGACATTGCACCGCGCCCCTCGTGGGGTCGCGTTGCCACC CCACGCGGACTCCCCAGCTGGCGCGCCCCTCCCATTTGCCTGTCCTGGTCAGGCCCCCAC CCCCCTTCCCACCTGACCAGCCATGGGGGCTGCGGTGTTTTTCGGCTGCACTTTCGTCGC GTTCGGCCCGGCCTTCGCGCTTTTCTTGATCACTGTGGCTGGGGACCCGCTTCGCGTTAT CATCCTGGTCGCAGGGTGAGTAGAGGGCCCGGGAGACGCGGGAGAGCGTCGAAGAGAGAG GTGCGGAAGGGGCTGGAGGAACTGGGGCAAGCCTGGGAGCCTGAATTGGGGACGATAAGT CGGAGGTGAAGTTTGGGCGGAGGTGAGGGGTTGGGTCTGGGAGATTTGTCCTTTCCCGCA GTTGGTTTCCACCTTCCAAGGATCTCACAGATTCCTCCTATATTCCTCCCAGCGACGTCA GAGAAGGCCCAAGGCCGAGACTCGTGAGGGGGCTGTGCTGACCTAGGCAGGCCGAGTCAG GTGCCTTAGGGGAGGATCCAGGAACGGATACCTCGCCCTTCCGTGCTCGCACACTCTGGC TGTCATCGCTCTGAAGACTCTTTAATTAGATTTCTCCCCTTTCCAGTGCGTTCACTTTTC TACAGATGAGTCTCTTGGTGGAGACAGTTACCCTACCTGGTCCATGTCTCCCTAACCATC CGGAAGGCTAACTTCCACTTTTCAAGCAGCTTTGGCTGGTTTCCCTCCTTGATTTCTCTG GCTCCCACTACTATTGCTTGTCTCACTGCCCCTGTCTTTTCTCAGGGCATTTTTCTGGCT GGTCTCCCTGCTCCTGGCCTCTGTGGTCTGGTTCATCTTGGTCCATGTGACCGACCGGTC AGATGCCCGGCTCCAGTACGGCCTCCTGATTTTTGGTGCTGCTGTCTCTGTCCTTCTACA GGAGGTGTTCCGCTTTGCCTACTACAAGCTGCTTAAGTAAGAAGATGGAGTGGTCTGGAG GGGAGAGGGGCAAAGGACTGCACTATGGGAAGTGGGGCAGCCCCTGGGTGCTGGTTTGGA AGAGGAGGCACTAAGGGAGGACATTAGAGGGAAAGGAGCATCCCTGCCCTCCCTCATGTT TCCCCTACCCCACCCCACCCCAGGAAGGCAGATGAGGGGTTAGCATCGCTGAGTGAGGAC GGAAGATCACCCATCTCCATCCGCCAGATGGCCTATGGTGAGCCAAGGGAGAGGGACTGG AGGAGGGAGTTGGACAGCCCCCTCCTCTAGGGAAGTCTCTAAATATCCACATGTTCTAAG TGGCTTCTTACTTTCCTTCATCCGTCACTTCCAAAGAAAGTTGGTCTGGAGGGAGAGTAG ATGTGAAAGAATTGTAACCGGGAATGGGGAGGGGTCAGTGGTGAACAGGCAATAGTGTGA TCTCTGACATTGATGAGATCCTCCCTTCCCCCAGTTTCTGGTCTCTCCTTCGGTATCATC AGTGGTGTCTTCTCTGTTATCAATATTTTGGCTGATGCACTTGGGCCAGGTGTGGTTGGG ATCCATGGAGACTCACCCTATTACTTCCTGACTTCAGGTAAGATCCACCTTCTATCTAGC CTTTACCCCCCATCCATCCTTGTCCCTGATCTGATTTATTGGCCTTCCCTGAGAGACTTC TTTGGCTCAACATCTCAGGAGCCTGGGAGAAGATCAGGGATGTATCTCCTCCCCATCTCC CTCCCTGCAGCCTTTCTGACAGCAGCCATTATCCTGCTCCATACCTTTTGGGGAGTTGTG TTCTTTGATGCCTGTGAGAGGAGACGGTACTGGGCTTTGGGCCTGGTGGTTGGGAGTCAC CTACTGACATCGGGACTGGTGAGTTGGAGACAGGGGCCTGAGTTAGGGAGAAAAGCATTT AATGGTGAGTGGGATGTGGGGGAAAGGGTATCCTCACTTCTTAACATTTTTAACTTACCT GGGAGGAGGAGGAAAGGTGAGTCTTTCAAGGTCTCTCACCTCAGCATCATTTCTATCACC TGCTCTGGGGAGGAGGTTGAAAGGATTAGTCAAACTGTAATGCAGAGGGCCTGAGGTGAG CAGGAGCGGCAGAAACCTTTGAGTTTCTGAGGAGCTGAAAATCAAAAGTCCCCTTAACCA CAAGATGTTGGTGCTCTGAAGGGAAAGACTGGAGAATTTGAGAGAGATATCTGGGAGTCA GAAAGGTACAGAGAGAATATGGGGATTAGGTCGAGGGAGAATCTAATCTCTTTCCTACTC TTACCCTCCTTCCTAGACATTCCTGAACCCCTGGTATGAGGCCAGCCTGCTGCCCATCTA TGCAGTCACTGTTTCCATGGGGCTCTGGGCCTTCATCACAGCTGGAGGGTCCCTCCGAAG TATTCAGCGCAGCCTCTTGTGTAAGGACTGACTACCTGGACTGATCGCCTGACAGATCCC ACCTGCCTGTCCACTGCCCATGACTGAGCCCAGCCCCAGCCCGGGTCCATTGCCCACATT CTCTGTCTCCTTCTCGTCGGTCTACCCCACTACCTCCAGGGTTTTGCTTTGTCCTTTTGT GACCGTTAGTCTCTAAGCTTTACCAGGAGCAGCCTGGGTTCAGCCAGTCAGTGACTGGTG GGTTTGAATCTGCACTTATCCCCACCACCTGGGGACCCCCTTGTTGTGTCCAGGACTCCC CCTGTGTCAGTGCTCTGCTCTCACCCTGCCCAAGACTCACCTCCCTTCCCCTCTGCAGGC CGACGGCAGGAGGACAGTCGGGTGATGGTGTATTCTGCCCTGCGCATCCCACCCGAGGAC TGAGGGAACCTAGGGGGGACCCCTGGGCCTGGGGTGCCCTCCTGATGTCCTCGCCCTGTA TTTCTCCATCTCCAGTTCTGGACAGTGCAGGTTGCCAAGAAAAGGGACCTAGTTTAGCCA TTGCCCTGGAGATGAAATTAATGGAGGCTCAAGGATAGATGAGCTCTGAGTTTCTCAGTA CTCCCTCAAGACTGGACATCTTGGTCTTTTTCTCAGGCCTGAGGGGGAACCATTTTTGGT GTGATAAATACCCTAAACTGCCTTTTTTTCTTTTTTGAGGTGGGGGGAGGGAGGAGGTAT ATTGGAACTCTTCTAACCTCCTTGGGCTATATTTTCTCTCCTCGAGTTGCTCCTCATGGC TGGGCTCATTTCGGTCCCTTTCTCCTTGGTCCCAGACCTTGGGGGAAAGGAAGGAAGTGC ATGTTTGGGAACTGGCATTACTGGAACTAATGGTTTTAACCTCCTTAACCACCAGCATCC CTCCTCTCCCCAAGGTGAAGTGGAGGGTGCTGTGGTGAGCTGGCCACTCCAGAGCTGCAG TGCCACTGGAGGAGTCAGACTACCATGACATCGTAGGGAAGGAGGGGAGATTTTTTTGTA GTTTTTAATTGGGGTGTGGGAGGGGCGGGGAGGTTTTCTATAAACTGTATCATTTTCTGC TGAGGGTGGAGTGTCCCATCCTTTTAATCAAGGTGATTGTGATTTTGACTAATAAAAAAG AATTTGTAATTGTG OMIM ID 607629