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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ANGPTL4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 51129 Official gene symbol ANGPTL4 Full name angiopoietin-like 4 Aliases ,ANGPTL2,ARP4,FIAF,HFARP,NL2,PGAR,pp1158, Gene summary This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq] Location Chromosome: 19   Locus: 19p13.3 Gene position 8429011 - 8439257  Map Viewer Gene orientation plus Gene size 10247 bp Gene sequence >ANGPTL4:1033007..1043253:Length=10247 ATAAAAACCGTCCTCGGGCGCGGCGGGGAGAAGCCGAGCTGAGCGGATCCTCACACGACT GTGATCCGATTCTTTCCAGCGGCTTCTGCAACCAAGCGGGTCTTACCCCCGGTCCTCCGC GTCTCCAGTCCTCGCACCTGGAACCCCAACGTCCCCGAGAGTCCCCGAATCCCCGCTCCC AGGCTACCTAAGAGGATGAGCGGTGCTCCGACGGCCGGGGCAGCCCTGATGCTCTGCGCC GCCACCGCCGTGCTACTGAGCGCTCAGGGCGGACCCGTGCAGTCCAAGTCGCCGCGCTTT GCGTCCTGGGACGAGATGAATGTCCTGGCGCACGGACTCCTGCAGCTCGGCCAGGGGCTG CGCGAACACGCGGAGCGCACCCGCAGTCAGCTGAGCGCGCTGGAGCGGCGCCTGAGCGCG TGCGGGTCCGCCTGTCAGGGAACCGAGGGGTCCACCGACCTCCCGTTAGCCCCTGAGAGC CGGGTGGACCCTGAGGTCCTTCACAGCCTGCAGGTACGTGTCCCCAGGGCTGGTTCTCCG CGCCCCTAGTGGCTCTCCTGGCTTGGAAGGGTATGGACAGGAGTGGGGCGTGGGGGCGGG GTGCGCAACTGTGGCTCCCTGGGCTTCCCTGCGTCAAGGGATGGGCTCCCCCCTTAGGAA GCCGAGGAGGGAGGTTCGCTCAAGGCCAGGAATTCAAGACCACCTAAAGCAAAATAGCGA GACCCCCGTCTCTTCTACACACACACACACACACACACAAAATAAATAAAATAAAATAAA ATAAATATAAAATTAAAAAACGACCGGGCGCAGTGGCTCACGGAGCCTCCACCTGCTGTC GAGACTAGCCTGGCCAACATGGAGAAACCTCGTCTCTACTAAAAATACAAAAAATTAGCC TGGCATGGTGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCTCT TGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCAGCACTGCACTCCAGCCTGGG CAACAGAGTGAGACTCCTCAAAAAAATAATAGCGATAAAATAAAAATAAAGCCAGGTGCG GTGACTCACGCTTGTAGTCCCAGCACTTTGGGAGGGCGAGGCCAGTGGATCACCTGAGGT CAGGAGTTCAAGACCAGCCTGACCAACACAGTGAAACCCCGTCTCTACTAAAAATACAAA AATTAGCTGGGTGTGGTGGTGGGCGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGG AGAACCTCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGGGATCATGCCATTGCACTC CAGCCTGGGCGACAGAGCTCGACTCCATCTCAAAATAATAATAATAATAAATAAAATAAA ATACAAATACAAAAATTAGCCAGGTGTGGTGGCAGCTACTTGGGAGGCTGAGACACAAGA ATCACTTGAGTCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCCACTGCACTCCAA CCTGGGTGACAGAGCGAGACTCTGTCTGAAAAAATAAAAAATAAGCCAGGCATAGAGCTG CATGACTGTAGTCCCAGCTACACAGGAGGCTGAAAACAGGAGGATCGCCTGACCCCAGGA GTTGGAGGCTGCAGTGAGCTGTGACAGCACCACTGCACTCCAGCCTGGGCGAGAGAACGA GACCCCGTCATTGGGAAAAAAAAGAAAAAAGAAAGACTCCCTTGCCTGGCCTCAGCGGAT GGAGATTTGGAAGGATGGATGAGTGGATGAATTAAGAGGTTGGGGTAGGCAAGCTGGGTC CTCACCAAGGTTTTCACCCCTCCCCAGACACAACTCAAGGCTCAGAACAGCAGGATCCAG CAACTCTTCCACAAGGTGGCCCAGCAGCAGCGGCACCTGGAGAAGCAGCACCTGCGAATT CAGCATCTGCAAAGCCAGGTAACCCTAGGATCAAGGGAGAAAAGGTCCCTCTGATAGCTG GACCCCAGGTTGAGAGGGAGGTGGTGAGAACTGGACGTGTGGCTGGGGACGTGGGGCCAG GCAGGACCTGACACCCTCCTCCCGTCCCATCCTAGTTTGGCCTCCTGGACCACAAGCACC TAGACCATGAGGTGGCCAAGCCTGCCCGAAGAAAGAGGCTGCCCGAGATGGCCCAGCCAG TTGACCCGGCTCACAATGTCAGCCGCCTGCACCGTGAGTGTCTGCCCCTCGATGCTCTCC GGTGGCCACCCCTACCCCGCCACTTGCCATTGCTGGTCCTCTCCTTGTCAGGTCCACCTT AAGGAGAAGATGTCCTGGCCTGGAGTCCCTGAGGGCTCACCAGTCTCTGGGTCAAAGCTG ATGGGAGCACCTCCTTCCTCAGCCCTGACCTGGCCCAGCCAGGCCACCCAACCCTTCTCC TCTGCAAGCCAGTGGGCTGTCCCTGAAGCCCTGCTGATCACTGATTGGAACAGAGGTGGA GAAAGAGGTCTTGAGGGACTTGAGCTGCAGGGGTGCTGGAGAAGGTAGAAATGGGGTTCG GGGTGCCATCCTGAAGGTTAGAACCTTCTAGGGGAGGGTGTCATGGAGGAGGGGGTGCCA GGTAGTAGTGTTTGTAGATTTGGGCCCTCCACAATGTCTTGGGGTATGTGGGAATTAGGG CTGGGAACCCCCAGCTCCCAGACCAGAAACACTCTTGTATCTTACAAATCCAATGCTCCA GGTCCCTGACCCCTCTTCCTCCTTCCTCTCTTGTTCTCCTCCTCCCTCCCCGCCCCCGCC GGCCCCCTCCCCACCGCAGAAAGTGGGCTTTTGCTGCCACCACAAGTTGTAGGTGCTTTA TTCCCAAATCTCCGTTCATCTCGAACCACAGCATGTCCACGTGTGTCCGATGCAGACTCG CGGTTCTCTAAGTTCACGGCCCCACACGGTTTCTCTGTGGTCCTCATCCTTCCCTGCATC TGTGGCTGTCCACAGCCAACTGGGTGAAAGTTTGGATCCCCCTCTCACACCCTAGGGTCA GTGGCAGGCTTCCAGCACTGTAGACCTGAGGGTTCTCTCCTCCCCAAGCTCCCGCTCCTT CCCACCTCCGTGCTGCCCGCCCCCAACCCCGCCAGGCTAGCATCTCAGCGTGGTCAGGGT CCTGTCCACCCTCCCAAAGCCACCATCCCAGGATGAGGGGCTTCTGGAGGGTGACGGGGG AAGGCACAAGTCCTGGCTGGGAAATGCGGTGGAAGGGGGCAGGGGTTCTGTGGGTTCGGG ACTCCCAGACTCTTGGCTCAGGCCCGCCAAGTAGGAGAAAGTTCAGAGCTGGGAAGGCGA ACAGCTGGCATTCATGGAAGCCACACTGGTGGTTTGGCCGCGTGCCCATCCTTACTGGAT GGGAGGAAAGTAGGGGAAAGGGGAGATGCCTGAGGGGCCGGAAAGCGTCTTCCTGGTCAC TCTGGGCCCGCCCCCACCCCCACCGTGCAGACTCATTTCGACCTTTCCCCTACTTTTCCG GCTGGGCTGGGGGCGGTTCCTCCCAGTCTGGAGCGTCTGAGCCTCCAGACGTGCTCAACG CCATCCTCCCCTCCTCCCTCCCTCTTTCTTTCCTCAACCCTGCCTCCTCTCCCTCTAGGA GCTGGGACCCCAGGCAGAGCCTCTGAGATGCTCCTGCTCAGCACAGTTCTTCCCGTTCTG GACCTGCTGCCTCATTCATTCATTCATTCATTCATTTGTCAAGACTGTTTTGTTTGCTTT TTGAGACGGAGTCTCGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCAC TGCAACCTCTGCCTCCCACTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCTCAAGTAGAT GGGATTATAGGCGCCTACCGCCACCACGCCCAGCTAATTTTTATTCATTTATCAAGTCTT TTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGTTGGAGTGCAATGGTTCAACCT CAGCTGACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCTGCCTCCTAAG GAGCTGGGATTACTGGCGTCCACCATCACACCCAGCTAATCTTTGTATGTTTTACTAGAG ATGGGGTTTGGCCATGTTGACCAGGCTGGTCTCAAACTCCTGACCGATCCGCCCGCCTCC CAAAGTGCTGGATTACAGGCATGAACCACTGCGCCCGGCCCATTCCTCAAGTCTTTATTG AGCAGCTGCTATGCGCTGGGGCCTGCGTGGATGCTGGTGCCAGGCTGTGGGCAGAGCTGC TCCTTGTCCCCAGCCTCATGGAGCCTCCATTGAGTCAGAGGAGAGACCATTAGATGACCT CAGTGTCCAGGAGTGGGAAGTCCTTGCTCAATTCCCATTTGGGGTGTTCTGGCCTGGTCT GGGGGTGAGGCAAGGCAGGGTGTCCTTCCAGAAGCTGGGACCCAGAGAGAGAAGTGAGGA AAGAGAGTCCCGCCGGGCGCAGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCCAA GGCTGGCGGATCACGAGGTCAGGAGATCGAGACCAGTCTGGCCAACATGGTGAAACCCCC GTCTCTACAAATAATGCAAAAACTAGTCGGGCGTGGTGGCACATGCCTGTAGTCCCAGCT GCTCCGGAGGCTGCGGCAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAG ATTGCGCCACTGCACTCCAGCCTGGCGACAGAGCGAGACTCCGTATCAAAAAACAAAACA AAAAAAGAGAGTCCCAGGCAGGGGGAACAGCATGTGCAAAGTCCCTGTGGCAGGACGGTG TGTGGTACAAGGGTGGGAAGAAAGCCTGTGTGCCAGAGAGGGTGTGGGTACAGCATGGCA GGAGGAGGATGGGCACGGGGGCTGGTCCTCCAGGTGCCTTGTGGACCATGCTGAGGAAGG ACATAGGGAGCCATGGAAGAGGTTAGGCAGATGGCAGAGAGGTGGTCATGAGATAAGATT TGCCTTTTACTTCCCTGGTCATCCACTGTTAAGCCCCCAGATATGCCTGGCTCCTGAGAC CCCCCCCAGGGGCTGCCCTCCTGTTTCAAGTCTCCACTTTATCTCCCTTCAGGGCTGCCC AGGGATTGCCAGGAGCTGTTCCAGGTTGGGGAGAGGCAGAGTGGACTATTTGAAATCCAG CCTCAGGGGTCTCCGCCATTTTTGGTGAACTGCAAGATGACCTCAGGTAGGGTGTGTTAG TCCACCAGGGGCCCCTCTCCCCATAGGCCCTGTTGTCTTTCTTTAAATTGAAAACAAAAC AAAACAAAAAAATTAAAGGCAGGGTCTTGCTATGTTGCCCAAGCTGGTCTTTTTTTTTTT TTTTTTTTTTGAGATGGAGTTTTGCTCTTGGAGCTGGAGTGCAATGCCACGATCTCAGCT CACTGAAACCTCCGCCTCCCGGGTTCAAGCAATTCTCCAGCGTCAGCCTCCCCAGTAGCT GAGACTACAGGTGCGAGCAACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACTGGG TTTCACCATGTTGGTCTGGCTGGTCTCAAACTCCTGACCTCAAATGATTTGCCGACTTTG GCCTCCCAAAATGCTGGGATTATAGGCATTAGCCACTGCTCCTGGCCTCTTTTCTTTAAA ATGCAGCCCTTGTCTGGGTGTAGTGGCTCATATCTGTAATCCCGACACTTTGGGAGGCCT ATCATGAGGATCACTTGAGCCCAGAAGTTCGAGACCAGCCTGGACAACATAGTGAGAGCT CATCTTTACAAAAAATTTTGTAAAAGTAAAAAAAAAGGCCAAGTGCAGTGGCTCACACCT GTAATCCCAGCACTTTGGGAGGTTGAGGCAGACAGATCACGAGGTCAGGAGTTCGAGACC AGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGGCATG GTGGTGTGCACCTGTAATCCCAGCTACTCAGGTGGCTGAGGCAGGAGAATCTCTTGAACC TGGGAGGCAGAGGTTGCAGTGAGCTGAGATGACGCCACCGCACTCCAGCCTGGGCGACAG AGCGAGACTCCGTCCCCCCATCAAAAAAATAAAAAAGAGAAAATAAAATAAAATAAAATA AAATTCAGCCCTTGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTCGGGAGGCC AAGGCAGGAGGGTCACTTCAGCCCAGGAGTTAAAGGCTGCCGTGAGCCGTGATCACACCT GTGAATAGCCACCGCACTCCAACCTGGGCAACACAACAAAACCTCGTTTCTAAAAAAAAA CAAAGGCTGAGCACGGTGGCTTACACCTGAAATGCCAGCACTTTGGGAGGCTGAGGCGGG CAAATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTATCTC TACCAACATAAACATTAGCCGGGCGTGCCTGTGATTCCAGCTGCTTGTGGGGCTGAAGCA CAAGAATCGCTTGAGCCCCGAAGGCAGAGGTTGCAGTGAGCTGAGATTGCGGCACTGCGA TCCAGCCTGGGCAACAGAGTGAGACTCCATCTCTAAAAAAAAAAAAAAAAAAAAAGAAAG CTTTTTTTTCCACTGAGAAGTCCTTTCCATTACAAGAGGTTACAACACGGGGTTTTACCC AGTTCAGCTGGCCCAGAGAGGCTTTGCAGATTTCCACTGCCTACTCCCTCCCACACTCAG TCCCTGCTGGGTTCTTGGGACAAAGATCTTCCCAAGGCCAGCCCATAATATTCCTCCCTC TGACCCACCCTCCTCGAGTCCTCCAGGGATGAGTGAGGGAGCTGCTGTCTTCCTGGGTTT GGAGGGGGTTTGGTGCTTGGCAGCCAGATGAGGGAGTGGGGTCGTCTGTGAAGAGGGACT TCCTGGTGACCTTGTACCTTTCTGGGCAGATGGAGGCTGGACAGTAATTCAGAGGCGCCA CGATGGCTCAGTGGACTTCAACCGGCCCTGGGAAGCCTACAAGGCGGGGTTTGGGGATCC CCACGGTAGGTGTTTCTAGTGGGGACAGAGGCAGGGGAGGAAGAGGGACCCTCAGAAGTG GCCCTGCCTCATGGAGTGGCCTCTCCCACTCCAGGCGAGTTCTGGCTGGGTCTGGAGAAG GTGCATAGCATCACGGGGGACCGCAACAGCCGCCTGGCCGTGCAGCTGCGGGACTGGGAT GGCAACGCCGAGTTGCTGCAGTTCTCCGTGCACCTGGGTGGCGAGGACACGGCCTATAGC CTGCAGCTCACTGCACCCGTGGCCGGCCAGCTGGGCGCCACCACCGTCCCACCCAGCGGC CTCTCCGTACCCTTCTCCACTTGGGACCAGGATCACGACCTCCGCAGGGACAAGAACTGC GCCAAGAGCCTCTCTGGTGAGCAGGCCCTGCCATGCCACACCCAGCCAGCAGCTTCCCTC CTTATCTTTCTGCTGCTCTGTCCTGCCTTCAACCCCACATTGCATCTGTTTCCTGCCCCC ACCTCTTCCTTACATGCCGTGTGTGTGATTGGGCCACTAACTTAGCCTATCTGGCCTCAG TTTTCCCATCCTGAAAAGGGTCTTGACCGTCTTTACTTTTATTTACTTATGTGTTTGTTT ATTTATTTATTTATGTATTTATTTTTTGAGACGGAGTCTCACTTTGTCACCCAGGCTGGA GTGCTTTGTGGCACGATCTTGGCTCACTGCAAGCTCCACCTCCTGAGTTCACACCATTCT CCTGCCTCAGCCTCCCGAGTAGCTGGGACTATAGGTGCCCACCACCACGCCTGGCTAATT TTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCC TGACCTCGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCAC CGCGCCCGGCCTACTTATTTATTTTTTGAGACAGAGTCCCGCTGTGTCTCCCAGGCTGGA GTGCAAGTGACGTGATCTTGGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTC CTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTTCCCGCCACCATGCACAGATAATTG TTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGGTGGTCTTGAACTCCT GACCTCAAGTGATCTGCCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCA CAATACCCGGCCACAAACATCTTTATAATGGTGCTCCACAGGATTCTTTTTTTTTTTTTT TTTTTGAAACAGGGTCTCACTCTGTTGCCTAAGCTGGAGTGCAGTGGTGCGATCTCGGCT CACTGCAACCTCCACCTCCCGGGTTCAAGCAATTCTCAAAAAAAAAAAAAAATTAGGCAC GGTGGCTCACACTTGCAATCCCAGCACTTTGGGAGGCTGAAGCGAGTGGATCACTTGAGC CCAGGAGACCAATCTGAGCAACAGGGCGAAATCCTGTCTCAATTAAAAATACAAAAAACT AGCTGGGCATGGTGGTGCCTGCCTGTGTTCCCATCTACTTGGGAGGCTGAGTTGGGAGGA TCTCTTGAGCCTAGGAGATAAGGCTGCAGTGAGCTGAGACTGCGCCACTGCACTCAAGCC TGGGTGACAGAGTGAGACCCCTGCCTCAAAAGAAAAAGAAAAAATGCAGGCATGGTGGCT CACACCTGTGGTCCCAGCTACTTGGGAGGCCCAGGTACAAGAATCACTTGAGCCCGTAAG GTTGACGCTGCATTGAGCCATCACCACACCACTGCACTCCAGCCTGGGCAATGGAGCCAG GCCCTGTCTCAAAAAAAATTGTTTTTAAACTTAAAAATAAGGCCGGGTGTGGGGGCTCAC ACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTC AAAACTAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGGCC AGGCGCAGTGGGTCATACCTGTAATCCCAGCACTTTGGGAGGCTGAGGAGGGTGGATCAC ATGAGGTAAGGAGTTTGAGACCAACCTGGCCAACATGGTGAAACCCCCTCACTACTAAAA ATACAAAAACTAGCCAGGCGTGGTGGCGGGTGCCTGTAATCCCGGCTACTCAGGAGGCTG AGGCATGAGAATCCCTTGAACCTGGGAGGCAGAGGTGCAGTGAGCCGAGATTGTGCCACT GCACTCCAGCCTGGGAGATAGAGTGAGACTCAGTCTCAAAAAAAAAGACCAAAAATTAGC CAGGTGTGGTGGCAGGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGGAGGAGAATCA CTTAAACCTGAGAGACGGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTG GGTGACAGAGTAAGACTCAATCTCAAAAAAAAAAAAGTCAAGTCCAAAGCCCAGCCTGGT CCCCAACCTGCCTCATCCTCAACCCTATCCCTATCTCCTTTCAGCCCCATCGGTGGCTCA AAGACCTGACCATGTTCCCTCTCCCCTGACCCCGGCAGGAGGCTGGTGGTTTGGCACCTG CAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCACAGCAGCGGCAGAAGCT TAAGAAGGGAATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCGCTGCAGGCCACCAC CATGTTGATCCAGCCCATGGCAGCAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTC CCAGGCCCACGAAAGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCT GGGCAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAGACCACGAC TGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTTGCCTCCTGAGATCGAGGC TGCAGGATATGCTCAGACTCTAGAGGCGTGGACCAAGGGGCATGGAGCTTCACTCCTTGC TGGCCAGGGAGTTGGGGACTCAGAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGG CGGACTCAGTCACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCAT GGTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAATGGTATCTG GGCGGAGCTCACAGAGTTCTTGGAATAAAAGCAACCTCAGAACACTT OMIM ID 605910