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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LEF1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51176
Official gene symbolLEF1
Full namelymphoid enhancer-binding factor 1
Aliases,DKFZp586H0919,FLJ46390,TCF1ALPHA,
Gene summaryThis gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q23-q25
Gene position109090112 - 108968701  Map Viewer
Gene orientationminus
Gene size121412 bp
Gene sequence
OMIM ID153245