Entrez gene ID | | 51422 |
Official gene symbol | | PRKAG2 |
Full name | | protein kinase, AMP-activated, gamma 2 non-catalytic subunit |
Aliases | | ,AAKG,AAKG2,CMH6,H91620p,WPWS, |
Gene summary | | AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q36.1 |
Gene position | | 151574316 - 151253200 Map Viewer |
Gene orientation | | minus |
Gene size | | 321117 bp |
Gene sequence |
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OMIM ID | | 602743 |
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