Entrez gene ID | | 51426 |
Official gene symbol | | POLK |
Full name | | polymerase (DNA directed) kappa |
Aliases | | ,DINB1,DINP,POLQ, |
Gene summary | | External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM] |
Location | | Chromosome: 5 Locus: 5q13 |
Gene position | | 74807657 - 74895646 Map Viewer |
Gene orientation | | plus |
Gene size | | 87990 bp |
Gene sequence |
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OMIM ID | | 605650 |
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