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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for POLK (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51426
Official gene symbolPOLK
Full namepolymerase (DNA directed) kappa
Aliases,DINB1,DINP,POLQ,
Gene summaryExternal and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM]
LocationChromosome: 5   Locus: 5q13
Gene position74807657 - 74895646  Map Viewer
Gene orientationplus
Gene size87990 bp
Gene sequence
OMIM ID605650