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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ANAPC5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51433
Official gene symbolANAPC5
Full nameanaphase promoting complex subunit 5
Aliases,APC5,
Gene summaryThis gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q24.31
Gene position121792012 - 121746048  Map Viewer
Gene orientationminus
Gene size45965 bp
Gene sequence
OMIM ID606948