Entrez gene ID | | 51611 |
Official gene symbol | | DPH5 |
Full name | | DPH5 homolog (S. cerevisiae) |
Aliases | | ,AD-018,CGI-30,HSPC143,MGC61450,NPD015, |
Gene summary | | This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p21.2 |
Gene position | | 101491362 - 101455179 Map Viewer |
Gene orientation | | minus |
Gene size | | 36184 bp |
Gene sequence |
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OMIM ID | | 611075 |