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Gene information for DPH5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51611
Official gene symbolDPH5
Full nameDPH5 homolog (S. cerevisiae)
Aliases,AD-018,CGI-30,HSPC143,MGC61450,NPD015,
Gene summaryThis gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p21.2
Gene position101491362 - 101455179  Map Viewer
Gene orientationminus
Gene size36184 bp
Gene sequence
OMIM ID611075